{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:07Z","timestamp":1760145127743,"version":"build-2065373602"},"reference-count":21,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> The objective of this case series was to assess the clinical outcomes of standard of care (SoC) supplemented with carePATCH (ExtremityCare LLC, US) a dehydrated, dual-layer amniotic membrane allograft, in mediating hard-to-heal wounds that had failed to respond to SoC alone. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Data were collected from electronic health records of patients seen between November 2023 and January 2025 at a single wound care provider group (WelsCare LLC, US). Patients aged \u226518 years with hard-to-heal wounds failing to achieve \u226550% surface area reduction within 30 days of documented SoC treatment were included. carePATCH was applied as an adjunct to SoC following debridement of the wound in accordance with best wound care practices. Changes in wound surface area, percentage area reduction (PAR) and clinical parameters were assessed at baseline, at final application and at one week post final application. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 13 patients (eight male, five female, mean age: 75.1 years) were included. A total of 13 wounds, including venous leg ulcers (n=6), pressure ulcers (n=5), post-surgical wounds (n=1) and venous stasis\/arterial wounds (n=1) were evaluated. Median PAR (for all wounds combined) at final application was 77.4%, increasing to 100% at one week post final application. Statistical analysis demonstrated significant improvement in PAR outcomes (p=0.017 at final application; p=0.003 at one week post final application). Box- and-whisker plots revealed consistent surface area reduction across all wound types, with measurements remaining stable one week post final application. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This case series provides encouraging results for the use of carePATCH as an adjunct to SoC in mediating chronic wounds. Patient outcome data support positive clinical experiences with regard to wound regression. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2025.0392","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:53:50Z","timestamp":1758196430000},"page":"805-815","source":"Crossref","is-referenced-by-count":0,"title":["Clinical experience depicting wound regression trends with carePATCH: a case series"],"prefix":"10.12968","volume":"34","author":[{"given":"Nan E","family":"Hodge","sequence":"first","affiliation":[{"name":"WelsCare LLC, Salt Lake City, Utah, US."},{"name":"WelsCare LLC, Greenville, SC, US."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey B","family":"Dahl","sequence":"additional","affiliation":[{"name":"WelsCare LLC, Salt Lake City, Utah, US."},{"name":"WelsCare LLC, Greenville, SC, US."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B","family":"Liljenquist","sequence":"additional","affiliation":[{"name":"WelsCare LLC, Salt Lake City, Utah, US."},{"name":"WelsCare LLC, Greenville, SC, US."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J","family":"Thomas","sequence":"additional","affiliation":[{"name":"WelsCare LLC, Salt Lake City, Utah, US."},{"name":"WelsCare LLC, Greenville, SC, US."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101072"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13953"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030655"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/term.2920"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14100531"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5772\/65321"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073406"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.069"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X211028298"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14272"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13071"},{"issue":"0","key":"B13","first-page":"153473462412766","volume":"0","author":"Lavery LA","year":"2025","journal-title":"Int J Low Extrem Wounds"},{"issue":"3","key":"B14","first-page":"70","volume":"28","author":"Snyder RJ","year":"2016","journal-title":"Wounds"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12227"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.11.530"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12843"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.Sup3.S24"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070829"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-022-00575-y"},{"issue":"3","key":"B21","first-page":"E36","volume":"30","author":"Regulski M","year":"2018","journal-title":"Wounds"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.Sup3.S44"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2025.0392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:04:36Z","timestamp":1760108676000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2025.0392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,2]]}},"alternative-id":["10.12968\/jowc.2025.0392"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2025.0392","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"type":"print","value":"0969-0700"},{"type":"electronic","value":"2052-2916"}],"subject":[],"published":{"date-parts":[[2025,10,2]]}}}