{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:17:12Z","timestamp":1791929832604,"version":"4.3.4"},"reference-count":23,"publisher":"Mark Allen Group","issue":"S11a","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"\n Objective:<\/jats:title>\n Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged \u226518 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as \u2018other\u2019 (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.<\/jats:p>\n <\/jats:sec>","DOI":"10.12968\/jowc.2025.0459","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:15:23Z","timestamp":1761135323000},"page":"S15-S24","source":"Crossref","is-referenced-by-count":1,"title":["Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies"],"prefix":"10.12968","volume":"34","author":[{"given":"Kirk","family":"Mitchell","sequence":"first","affiliation":[{"name":"Compassionate Concierge Physicians, Longmont, CO, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"B2","unstructured":"Labib A, Winters R. Complex wound management. StatPearls Publishing. 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK576385\/ (accessed 9 October 2025)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0026"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070829"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073406"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.Sup4b.S1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14888"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.63676\/fr1wc427"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-023-06740-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/term.3086"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33265"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12843"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.0139"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2019-0142"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12954"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14339"},{"issue":"3","key":"B21","first-page":"E36","volume":"30","author":"Regulski M","year":"2018","journal-title":"Wounds"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2025.0022"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-023-10100-5"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2025.0459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:40:10Z","timestamp":1765471210000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2025.0459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":23,"journal-issue":{"issue":"S11a","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.12968\/jowc.2025.0459"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2025.0459","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]}}}