{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:04:49Z","timestamp":1791893089944,"version":"4.3.4"},"reference-count":52,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Hard-to-heal (chronic) venous leg ulcers (VLUs) are challenging to heal with standard of care (SoC) alone. This study evaluated whether adding a thigh-administered intermittent pneumatic compression (IPC) device (WoundExpress, Huntleigh Healthcare Ltd., UK) to SoC improved outcomes in patients with hard-to-heal venous or mixed leg ulcers (venous and arterial), was suitable for home use and was safe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A multicentre, pragmatic, open-label, randomised controlled trial (RCT) was conducted across the UK, US, Germany and France. Adults with hard-to-heal lower limb VLUs and mixed ulcers already receiving compression were randomised 1:1 to adjunctive IPC (two hours\/day; intervention) plus SoC, or SoC alone (control), for 16 weeks. The primary outcome was percentage change in wound area. Secondary outcomes included: complete healing; wound pain; quality of life (QoL); acceptability; usage; and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 136 patients were randomised (n=65 IPC; n=71 control); 116 patients completed the study. Median wound area reduction at 16 weeks was similar: (intervention: 64.0% versus control: 67.7%; p=0.35). Complete healing occurred in 16.9% (IPC) and 18.3% (control) patients (p=0.80). Pain scores and QoL improved modestly in both groups, with no between-group differences. The IPC device was well tolerated: 64% of patients rated it \u2018very good\u2019 or \u2018excellent\u2019. Mean use was ~2.0 hours\/day, as reported in patient diaries. Adverse events were primarily mild and comparable (54% IPC; 59% control); only one mild event was device-related.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this RCT, thigh-administered IPC did not improve healing beyond SoC in this patient population, although it was safe, well-tolerated, and feasible for home use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2026.0047","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:56:37Z","timestamp":1791395797000},"page":"901-914","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent pneumatic thigh compression for the treatment of lower limb wounds (IPCOTT): a randomised control trial"],"prefix":"10.12968","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-0489","authenticated-orcid":false,"given":"David C","family":"Bosanquet","sequence":"first","affiliation":[{"name":"Welsh Wound Innovation Centre, Wales, UK"},{"name":"South East Wales Vascular Network, University Hospital of Wales, Cardiff, UK"},{"name":"Division of Population Medicine, Cardiff University School of Medicine, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane H","family":"Davies","sequence":"additional","affiliation":[{"name":"Cardiff &amp; Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ivins","sequence":"additional","affiliation":[{"name":"Welsh Wound Innovation Centre, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Welsh Wound Innovation Centre, Wales, UK"},{"name":"Wound Healing Solutions Ltd, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Kettley","sequence":"additional","affiliation":[{"name":"Welsh Wound Innovation Centre, Wales, UK"},{"name":"University of South Wales, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Cocks","sequence":"additional","affiliation":[{"name":"KCStats Consultancy, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Harding","sequence":"additional","affiliation":[{"name":"Professor Emeritus, Cardiff University, Wales, UK"},{"name":"Adjunct Professor, Monash University, Malaysia"},{"name":"Co-Founder and Editor-in-Chief, International Wound Journal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X211028298"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14272"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13026"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009283"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045253"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62368-5"},{"key":"e_1_3_3_8_2","first-page":"e6","article-title":"Faster healing and a lower rate of recurrence of venous ulcers treated with intermittent pneumatic compression: results of a randomized controlled trial","volume":"20","author":"Alvarez OM","year":"2020","unstructured":"Alvarez OM, Markowitz L, Parker R, Wendelken ME. 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