{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T17:48:34Z","timestamp":1782064114832,"version":"3.54.5"},"reference-count":23,"publisher":"Mark Allen Group","issue":"LatAm-Sup6e","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objetivo:<\/jats:title>\n                    <jats:p>Analizar la efectividad de la ozonoterapia en comparaci\u00f3n con ap\u00f3sitos de cloruro de diaquilcarbamilo (DACC, por sus siglas en ingl\u00e9s) en el tratamiento de \u00falceras neurop\u00e1ticas en los miembros inferiores causadas por diabetes mellitus (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Metodolog\u00eda:<\/jats:title>\n                    <jats:p>Serie de casos de estudio, realizados en la cl\u00ednica ambulatoria de un hospital universitario en el sur de Brasil. Se seleccionaron pacientes con \u00falceras neurop\u00e1ticas en los miembros inferiores causadas por DM entre noviembre de 2021 y enero de 2022. La muestra estuvo compuesta por seis pacientes, divididos en tres grupos de forma equitativa: grupo DACC, grupo ozono y grupo control activo. La recolecci\u00f3n de datos se realiz\u00f3 a trav\u00e9s de consultas presenciales dos veces por semana, siguiendo el protocolo correspondiente a cada grupo. Los resultados fueron tabulados y sometidos a an\u00e1lisis estad\u00edstico.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Resultados:<\/jats:title>\n                    <jats:p>Los grupos DACC y ozono mostraron una mayor reducci\u00f3n del \u00e1rea de la lesi\u00f3n. El grupo control activo present\u00f3 un mayor porcentaje de proliferaci\u00f3n de tejido de granulaci\u00f3n, aunque sin significancia estad\u00edstica. En cuanto al exudado, s\u00f3lo se evidenci\u00f3 una reducci\u00f3n en la cantidad, siendo m\u00e1s notable en el grupo de ozono, pero sin eliminaci\u00f3n completa del mismo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusi\u00f3n:<\/jats:title>\n                    <jats:p>Los pacientes tratados \u00fanicamente con ozono y aquellos tratados s\u00f3lo con DACC mostraron una mayor reducci\u00f3n del \u00e1rea de la lesi\u00f3n, as\u00ed como un incremento en la proliferaci\u00f3n tisular, evidenciado por el aumento del tejido de granulaci\u00f3n. Adem\u00e1s, la ozonoterapia ayud\u00f3 a reducir la cantidad de exudado.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/jowc.2026.0253","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:40:16Z","timestamp":1781199616000},"source":"Crossref","is-referenced-by-count":0,"title":["Efectividad de la ozonoterapia en el tratamiento de \u00falceras neurop\u00e1ticas en miembros inferiores con diabetes mellitus"],"prefix":"10.12968","volume":"35","author":[{"given":"Geovana","family":"Schmidt","sequence":"first","affiliation":[{"name":"Universidad Estatal del Oeste de Paran\u00e1, Departamento de Enfermer\u00eda, Cascavel, Paran\u00e1, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ampessan","sequence":"additional","affiliation":[{"name":"Universidad Estatal del Oeste de Paran\u00e1, Departamento de Enfermer\u00eda, Cascavel, Paran\u00e1, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo Passoni","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Universidad Estatal del Oeste de Paran\u00e1, Departamento de Enfermer\u00eda, Cascavel, Paran\u00e1, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"de Souza Silva Freitas","sequence":"additional","affiliation":[{"name":"Universidad Federal de Esp\u00edrito Santo, Departamento de Enfermer\u00eda, Vit\u00f3ria, Esp\u00edrito Santo, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Aparecida","family":"de Barros","sequence":"additional","affiliation":[{"name":"Essity."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana Rodrigues","family":"da Silva Carvalho","sequence":"additional","affiliation":[{"name":"Universidad Estatal del Oeste de Paran\u00e1, Departamento de Enfermer\u00eda, Cascavel, Paran\u00e1, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edsio Vitor Augusto","family":"Lordani","sequence":"additional","affiliation":[{"name":"Universidad Estatal del Oeste de Paran\u00e1, Departamento de Enfermer\u00eda, Cascavel, Paran\u00e1, Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"e_1_3_1_1_1","unstructured":"1 Minist\u00e9rio da Sa\u00fade Brasil. Diabetes (diabetes mellitus): sintomas causas e tratamentos. 2019. http:\/\/antigo.saude.gov.br\/saude-de-a-z\/diabete"},{"key":"e_1_3_1_2_1","unstructured":"2 International Diabetes Federation. Diabetes facts & figures. 2021. https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes\/facts-figures.html"},{"key":"e_1_3_1_3_1","volume-title":"Departamento de epidemiologia, economia e sa\u00fade p\u00fablica","author":"Sociedade Brasileira de Diabetes","year":"2019","unstructured":"3 Sociedade Brasileira de Diabetes, Departamento de epidemiologia, economia e sa\u00fade p\u00fablica. Dados epidemiol\u00f3gicos do diabetes mellitus no Brasil. 2019. https:\/\/diabetes.org.br\/wp-content\/uploads\/2021\/06\/SBD_Dados_Epidemiologicos_do_Diabetes_-_High_Fidelity.pdf"},{"key":"e_1_3_1_4_1","unstructured":"4 Minist\u00e9rio da Sa\u00fade Brasil Secretaria de Estado de Sa\u00fade do Distrito Federal Grupo de Trabalho Internacional sobre P\u00e9 Diab\u00e9tico. Consenso internacional sobre p\u00e9 diab\u00e9tico. 2001. http:\/\/189.28.128.100\/dab\/docs\/publicacoes\/geral\/conce_inter_pediabetico.pdf"},{"key":"e_1_3_1_5_1","unstructured":"5 Minist\u00e9rio da Sa\u00fade Brasil. Hipertens\u00e3o arterial sist\u00eamica (HAS) e Diabetes mellitus (DM). 2001. https:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/cd05_06.pdf"},{"key":"e_1_3_1_6_1","unstructured":"6 Minist\u00e9rio da Sa\u00fade Brasil. Manual do p\u00e9 diab\u00e9tico: estrat\u00e9gias para o cuidado da pessoa com doen\u00e7a cr\u00f4nica. 2016. https:\/\/biblioteca.cofen.gov.br\/manual-do-pe-diabetico\/"},{"key":"e_1_3_1_7_1","unstructured":"7 Gu\u00edas del IWGDF para la prevenci\u00f3n y el manejo de la enfermedad del pie relacionada con la diabetes. 2023 https:\/\/iwgdfguidelines.org\/wp-content\/uploads\/2024\/09\/Guia-Espanol-IWGDF-2023.pdf"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.08.020"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0018"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","unstructured":"10 Zhang J Guan M Xie C Luo X Zhang Q Xue Y. Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxidative Med Cellular Longevity. 2014: 1\u20138. 10.1155\/2014\/273475","DOI":"10.1155\/2014\/273475"},{"issue":"1","key":"e_1_3_1_11_1","first-page":"7","article-title":"Ozone therapy effectiveness in patients with ulcerous lesion due to diabetes ellitus","volume":"69","author":"Rosul M","year":"2016","unstructured":"11 Rosul M, Patskan BM. Ozone therapy effectiveness in patients with ulcerous lesion due to diabetes ellitus. Wiad Lek. 2016;69(1):7\u20139. https:\/\/dspace.uzhnu.edu.ua\/jspui\/bitstream\/lib\/8745\/1\/selection.pdf","journal-title":"Wiad Lek"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.060"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2012.21.sup2.4"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010089"},{"key":"e_1_3_1_16_1","unstructured":"16 International Diabetes Federation. The diabetic foot. 2020. https:\/\/www.idf.org\/our-activities\/care-prevention\/diabetic-foot.html (acesso 16 julio 2025)"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/1518-8345.1203.2761"},{"key":"e_1_3_1_18_1","unstructured":"18 Sociedade Brasileira de Diabetes. Diretrizes da sociedade brasileira de diabetes 2019-2020. 2019. https:\/\/www.saude.ba.gov.br\/wp-content\/uploads\/2020\/02\/Diretrizes-Sociedade-Brasileira-de-Diabetes-2019-2020.pdf"},{"issue":"7","key":"e_1_3_1_19_1","article-title":"Use of a DACC-coated antimicrobial dressing in people with diabetes and a history of foot ulceration","volume":"1","author":"Haycocks S","year":"2011","unstructured":"19 Haycocks S, Chadwick P, Guttormsen K. Use of a DACC-coated antimicrobial dressing in people with diabetes and a history of foot ulceration. Wounds UK. 2011;1(7). https:\/\/www.woundsinternational.com\/uploads\/resources\/content_9824.pdf","journal-title":"Wounds UK"},{"issue":"15","key":"e_1_3_1_20_1","article-title":"Beneficios de la intervenci\u00f3n con ozonoterapia em pacientes con pie diab\u00e9tico neuroinfeccioso","volume":"1","author":"Duarte ASHA","year":"2014","unstructured":"20 Duarte ASHA, Highwayman JH, Rock YH et al. Beneficios de la intervenci\u00f3n con ozonoterapia em pacientes con pie diab\u00e9tico neuroinfeccioso. Revista Cubana Angiologia Cirurgia Vascascular. 2014;1(15). http:\/\/scielo.sld.cu\/scielo.php?script=sci_arttext&pid=S1682-00372014000100003","journal-title":"Revista Cubana Angiologia Cirurgia Vascascular"},{"issue":"17","key":"e_1_3_1_21_1","first-page":"2735","article-title":"Banho de oxig\u00eanio m\u00e9dico no tratamento de feridas infectadas de \u00falceras do p\u00e9 diab\u00e9tico","volume":"24","author":"Qin X","year":"2020","unstructured":"21 Qin X, Wang L, Wang J. Banho de oxig\u00eanio m\u00e9dico no tratamento de feridas infectadas de \u00falceras do p\u00e9 diab\u00e9tico. Chin J Tissue Engin Res. 2020;24(17):2735\u20132741. https:\/\/www.cjter.com\/\/CN\/10.3969\/j.issn.2095-4344.2676","journal-title":"Chin J Tissue Engin Res"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731447"},{"key":"e_1_3_1_23_1","unstructured":"23 World Union of Wound Healing Societies. Principles of best practice: wound exudate and the role of dressings. 2007. https:\/\/woundsinternational.com\/wp-content\/uploads\/2023\/02\/6456db7c0301d230443b7144d4b3e7c0.pdf"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"es","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2026.0253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T17:40:50Z","timestamp":1782063650000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2026.0253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":23,"journal-issue":{"issue":"LatAm-Sup6e","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.12968\/jowc.2026.0253"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2026.0253","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}