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Persani,              L, Brabant,                G, Dattani,                M, Bonomi,                M,                Feldt-Rasmussen,              U, Fliers,                E, et al.            2018 European Thyroid Association (ETA) guidelines on the diagnosis and            management of central hypothyroidism. Eur Thyroid J          2018;7: 225\u201337.","DOI":"10.1159\/000491388"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Joustra,                SD, Heinen,                CA,                Schoenmakers,              N, Bonomi,                M,              Ballieux, BE,                Turgeon,            MO, et al.            IGSF1 Clinical Care Group. IGSF1 deficiency:            Lessons from an extensive case series and recommendations for clinical            management. J Clin Endocrinol Metab          2016;101: 1627\u201336.","DOI":"10.1210\/jc.2015-3880"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Sugisawa,                C,                Takamizawa,              T, Abe,                K,              Hasegawa, T,                Shiga, K,                Sugawara,            H, et al.            Genetics of congenital isolated TSH deficiency: Mutation screening of the            known causative genes and a literature review. J Clin Endocrinol            Metab          2019;104: 6229\u201337.","DOI":"10.1210\/jc.2019-00657"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Naafs,              JC, Verkerk,                PH, Fliers,                E, van                Trotsenburg, ASP,                Zwaveling-Soonawala,              N. Clinical and            genetic characteristics of Dutch children with central congenital hypothyroidism, early            detected by neonatal screening. Eur J Endocrinol          2020;183: 627\u201336.","DOI":"10.1530\/EJE-20-0833"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Joustra,                SD, van                Trotsenburg, AS,                Sun, Y,                Losekoot,            M, Bernard,                DJ,                Biermasz,              NR, et al.            IGSF1 deficiency syndrome: A newly uncovered            endocrinopathy. Rare Dis          2013;1: e24883.","DOI":"10.4161\/rdis.24883"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Tajima,              T, Nakamura,                A,              Morikawa, S,                Ishizu,            K. Neonatal            screening and a new cause of congenital central hypothyroidism.            Ann Pediatr Endocrinol Metab          2014;19: 117\u201321.","DOI":"10.6065\/apem.2014.19.3.117"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Sun,              Y, Bak,                B,                Schoenmakers,              N, van                Trotsenburg, AS,                Oostdijk,            W, Voshol,                P, et al.            Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central            hypothyroidism and testicular enlargement. Nat Genet          2012;44: 1375\u201381.","DOI":"10.1530\/endoabs.31.OC2.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Robakis,              T, Bak,                B, Lin,                SH,              Bernard, DJ,                Scheiffele,              P. An internal            signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain            protein. J Biol Chem          2008;283: 36369\u201376.","DOI":"10.1074\/jbc.M807527200"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Br\u00fbl\u00e9,              E, Silander,                TL, Wang,                Y, Zhou,                X, Bak,                B,                Groeneweg,              S, et al.            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J Clin Endocrinol            Metab          2013;98: E1682\u201391.","DOI":"10.1210\/jc.2013-1224"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Tenenbaum-Rakover,                Y, Turgeon,                MO, London,                S,              Hermanns, P,                Pohlenz, J,                Bernard,            DJ, et al.            Familial central hypothyroidism caused by a novel IGSF1 gene            mutation. Thyroid          2016;26: 1693\u2013700.","DOI":"10.1089\/thy.2015.0672"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Van                Hulle, S,                Craen, M,                Callewaert,              B, Joustra,                S,              Oostdijk, W,                Losekoot,            M, et al.            Delayed adrenarche may be an additional feature of immunoglobulin super            family member 1 deficiency syndrome. 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Standards and guidelines for the interpretation of sequence variants: a            joint consensus recommendation of the American College of Medical Genetics and Genomics            and the Association for Molecular Pathology. Genet Med          2015;17: 405\u201324.","DOI":"10.1038\/gim.2015.30"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Tajima,              T, Nakamura,                A, Oguma,                M,              Yamazaki,            M. Recent            advances in research on isolated congenital central hypothyroidism.            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