{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:33:24Z","timestamp":1792762404259,"version":"4.5.0"},"reference-count":43,"publisher":"Japanese Society for Pediatric Endocrinology","issue":"1","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K11662"],"award-info":[{"award-number":["21K11662"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr Endocrinol"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1297\/cpe.2025-0051","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:07:51Z","timestamp":1759961271000},"page":"67-73","source":"Crossref","is-referenced-by-count":1,"title":["The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents"],"prefix":"10.1297","volume":"35","author":[{"given":"Junji","family":"Takaya","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kawachi General Hospital, Osaka, Japan"},{"name":"Department of Pediatrics, Kansai Medical University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kansai Medical University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kansai Medical University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kansai Medical University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kawachi General Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kawachi General Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kansai Medical University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"125","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Dale, HH. On some physiological actions of ergot. J Physiol 1906;34: 163\u2013206.","DOI":"10.1113\/jphysiol.1906.sp001148"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Aoki, Y, Yahata, N, Watanabe, T, Takano, Y, Kawakubo, Y, Kuwabara, H, et al. Oxytocin improves behavioural and neural deficits in inferring others\u2019 social emotions in autism. Brain 2014;137: 3073\u201386.","DOI":"10.1093\/brain\/awu231"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Nagasawa, M, Okabe, S, Mogi, K, Kikusui, T. Oxytocin and mutual communication in mother-infant bonding. Front Hum Neurosci 2012;6: 31.","DOI":"10.3389\/fnhum.2012.00031"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Kosfeld, M, Heinrichs, M, Zak, PJ, Fischbacher, U, Fehr, E. Oxytocin increases trust in humans. Nature 2005;435: 673\u20136.","DOI":"10.1038\/nature03701"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Maejima, Y, Aoyama, M, Sakamoto, K, Jojima, T, Aso, Y, Takasu, K, et al. Impact of sex, fat distribution and initial body weight on oxytocin\u2019s body weight regulation. Sci Rep 2017;7: 8599.","DOI":"10.1038\/s41598-017-09318-7"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Maejima, Y, Sedbazar, U, Suyama, S, Kohno, D, Onaka, T, Takano, E, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 2009;10: 355\u201365.","DOI":"10.1016\/j.cmet.2009.09.002"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wu, Z, Xu, Y, Zhu, Y, Sutton, AK, Zhao, R, Lowell, BB, et al. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One 2012;7: e45167.","DOI":"10.1371\/journal.pone.0045167"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Blevins, JE, Graham, JL, Morton, GJ, Bales, KL, Schwartz, MW, Baskin, DG, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 2015;308: R431\u20138.","DOI":"10.1152\/ajpregu.00441.2014"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zhang, H, Wu, C, Chen, Q, Chen, X, Xu, Z, Wu, J, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One 2013;8: e61477.","DOI":"10.1371\/journal.pone.0061477"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lawson, EA, Marengi, DA, DeSanti, RL, Holmes, TM, Schoenfeld, DA, Tolley, CJ. Oxytocin reduces caloric intake in men. Obesity (Silver Spring) 2015;23: 950\u20136.","DOI":"10.1002\/oby.21069"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Morton, GJ, Thatcher, BS, Reidelberger, RD, Ogimoto, K, Wolden-Hanson, T, Baskin, DG, et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab 2012;302: E134\u201344.","DOI":"10.1152\/ajpendo.00296.2011"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Maejima, Y, Iwasaki, Y, Yamahara, Y, Kodaira, M, Sedbazar, U, Yada, T. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY) 2011;3: 1169\u201377.","DOI":"10.18632\/aging.100408"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yi, CX, Tsch\u00f6p, MH. Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech 2012;5: 583\u20137.","DOI":"10.1242\/dmm.009902"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Velmurugan, S, Russell, JA, Leng, G. Systemic leptin increases the electrical activity of supraoptic nucleus oxytocin neurones in virgin and late pregnant rats. J Neuroendocrinol 2013;25: 383\u201390.","DOI":"10.1111\/jne.12016"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. American Diabetes Association.Type 2 diabetes in children and adolescents. Pediatrics 2000;105: 671\u201380.","DOI":"10.1542\/peds.105.3.671"},{"key":"16","unstructured":"16. Murata, M, Ito, K. On the optimal weight in school age children. In: Murata M, editor. Report of research on nutrition, exercise and recreation from the viewpoint of health and QOL in children, supported by Health, Labour and Welfare for research on Health Services in 2002.  2003(in Japanese)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Dobashi, K. Evaluation of obesity in school-age children. J Atheroscler Thromb 2016;23: 32\u20138.","DOI":"10.5551\/jat.29397"},{"key":"18","unstructured":"18. Kato, N. Construction of BMI for age references for Japanese children from the 2000 national growth survey. J Japan Assoc Hum Auxol 2009;15: 37\u201344."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Pataky, Z, Guessous, I, Caillon, A, Golay, A, Rohner-Jeanrenaud, F, Altirriba, J. Variable oxytocin levels in humans with different degrees of obesity and impact of gastric bypass surgery. Int J Obes (Lond) 2019;43: 1120\u20134.","DOI":"10.1038\/s41366-018-0150-x"},{"key":"20","unstructured":"20. Stock, S, Granstr\u00f6m, L, Backman, L, Matthiesen, AS, Uvn\u00e4s-Moberg, K. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int J Obes (Lond) 1989;13: 213\u201322."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Blevins, JE, Baskin, DG. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiol Behav 2015;152(Pt B): 438\u201349.","DOI":"10.1016\/j.physbeh.2015.05.023"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lawson, EA, Olszewski, PK, Weller, A, Blevins, JE. The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis. J Neuroendocrinol 2020;32: e12805.","DOI":"10.1111\/jne.12805"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. McCormack, SE, Blevins, JE, Lawson, EA. Metabolic effects of oxytocin. Endocr Rev 2020;41: 121\u201345.","DOI":"10.1210\/endrev\/bnz012"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Maejima, Y, Rita, RS, Santoso, P, Aoyama, M, Hiraoka, Y, Nishimori, K, et al. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology 2015;101: 35\u201344.","DOI":"10.1159\/000371636"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Klockars, A, Brunton, C, Li, L, Levine, AS, Olszewski, PK. Intravenous administration of oxytocin in rats acutely decreases deprivation-induced chow intake, but it fails to affect consumption of palatable solutions. Peptides 2017;93: 13\u20139.","DOI":"10.1016\/j.peptides.2017.04.010"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Edwards, MM, Nguyen, HK, Herbertson, AJ, Dodson, AD, Wietecha, T, Wolden-Hanson, T, et al. Chronic hindbrain administration of oxytocin elicits weight loss in male diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 2021;320: R471\u201387.","DOI":"10.1152\/ajpregu.00294.2020"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Coiro, V, Passeri, M, Davoli, C, d\u2019Amato, L, Gelmini, G, Fagnoni, F, et al. Oxytocin response to insulin-induced hypoglycemia in obese subjects before and after weight loss. J Endocrinol Invest 1988;11: 125\u20138.","DOI":"10.1007\/BF03350119"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Qian, W, Zhu, T, Tang, B, Yu, S, Hu, H, Sun, W, et al. Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients. J Clin Endocrinol Metab 2014;99: 4683\u20139.","DOI":"10.1210\/jc.2014-2206"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Binay, \u00c7, Paket\u00e7i, C, G\u00fczel, S, Samanc\u0131, N. Serum irisin and oxytocin levels as predictors of metabolic parameters in obese children. J Clin Res Pediatr Endocrinol 2017;9: 124\u201331.","DOI":"10.4274\/jcrpe.3963"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Mekki, LB, Elhassan, YH, Badi, RM, Shazali, AF, Mojaddidi, MA, Ibrahim, S, et al. Elevated oxytocin levels and their relationship to metabolic syndrome and obesity among young Sudanese adults: a cross-sectional analysis. Cureus 2025;17: e81451.","DOI":"10.7759\/cureus.81451"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Yuan, G, Qian, W, Pan, R, Jia, J, Jiang, D, Yang, Q, et al. Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome. Endocr J 2016;63: 655\u201362.","DOI":"10.1507\/endocrj.EJ16-0078"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Maestrini, S, Mele, C, Mai, S, Vietti, R, Di Blasio, A, Castello, L, et al. Plasma oxytocin concentration in pre- and postmenopausal women: its relationship with obesity, body composition and metabolic variables. Obes Facts 2018;11: 429\u201339.","DOI":"10.1159\/000492001"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Eisenberg, Y, Dugas, LR, Akbar, A, Reddivari, B, Layden, BT, Barengolts, E. Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors. PLoS One 2018;13: e0190301.","DOI":"10.1371\/journal.pone.0190301"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Garcia-Mayor, RV, Andrade, MA, Rios, M, Lage, M, Dieguez, C, Casanueva, FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 1997;82: 2849\u201355.","DOI":"10.1210\/jc.82.9.2849"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Ellis, KJ, Nicolson, M. Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development. Pediatr Res 1997;42: 484\u20138.","DOI":"10.1203\/00006450-199710000-00010"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. B\u00f6ttner, A, Kratzsch, J, M\u00fcller, G, Kapellen, TM, Bl\u00fcher, S, Keller, E, et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004;89: 4053\u201361.","DOI":"10.1210\/jc.2004-0303"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Kelsey, MM, Zeitler, PS. Insulin resistance of puberty. Curr Diab Rep 2016;16: 64.","DOI":"10.1007\/s11892-016-0751-5"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Hannon, TS, Janosky, J, Arslanian, SA. Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res 2006;60: 759\u201363.","DOI":"10.1203\/01.pdr.0000246097.73031.27"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Kurto\u011flu, S, Hatipo\u011flu, N, Maz\u0131c\u0131o\u011flu, M, Kendirici, M, Keskin, M, Kondolot, M. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010;2: 100\u20136.","DOI":"10.4274\/jcrpe.v2i3.100"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40. Kim, YW, Kim, JY, Park, YH, Park, SY, Won, KC, Choi, KH, et al. Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Diabetes 2006;55: 716\u201324.","DOI":"10.2337\/diabetes.55.03.06.db05-0917"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Blevins, JE, Schwartz, MW, Baskin, DG. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol 2004;287: R87\u201396.","DOI":"10.1152\/ajpregu.00604.2003"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Perello, M, Raingo, J. Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents. PLoS One 2013;8: e59625.","DOI":"10.1371\/journal.pone.0059625"},{"key":"43","doi-asserted-by":"publisher","unstructured":"43. Maejima, Y, Yokota, S, Nishimori, K, Shimomura, K. The anorexigenic neural pathways of oxytocin and their clinical implication. Neuroendocrinology 2018;107: 91\u2013104.","DOI":"10.1159\/000489263"}],"container-title":["Clinical Pediatric Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/35\/1\/35_2025-0051\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:21:29Z","timestamp":1768018889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/35\/1\/35_2025-0051\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1297\/cpe.2025-0051","relation":{},"ISSN":["0918-5739","1347-7358"],"issn-type":[{"value":"0918-5739","type":"print"},{"value":"1347-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025-0051"}}