{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:56:08Z","timestamp":1790999768997,"version":"4.1.0"},"reference-count":29,"publisher":"Japanese Society for Pediatric Endocrinology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr Endocrinol"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1297\/cpe.2026-0043","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:10:25Z","timestamp":1784153425000},"page":"310-318","source":"Crossref","is-referenced-by-count":0,"title":["Radioiodine or thyroidectomy in children and adolescents with Graves\u2019 disease: a structured literature review of efficacy and safety"],"prefix":"10.1297","volume":"35","author":[{"given":"Irene","family":"Silvestrini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"Enezari","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gatta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy"},{"name":"Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy"},{"name":"Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"125","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Antonelli, A, Ferrari, SM, Ragusa, F, Elia, G, Paparo, SR, Ruffilli, I, et al. Graves\u2019 disease: Epidemiology, genetic and environmental risk factors and viruses. Best Pract Res Clin Endocrinol Metab 2020;34: 101387.","DOI":"10.1016\/j.beem.2020.101387"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Smith, TJ, Heged\u00fcs, L. Graves\u2019 disease. N Engl J Med 2016;375: 1552\u201365.","DOI":"10.1056\/NEJMra1510030"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. L\u00e9ger, J. Graves\u2019 disease in children. Endocr Dev 2014;26: 171\u201382.","DOI":"10.1159\/000363163"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Vaidyanathan, P. Update on Pediatric Hyperthyroidism. Adv Pediatr 2022;69: 219\u201329.","DOI":"10.1016\/j.yapd.2022.04.004"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Mooij, CF, Cheetham, TD, Verburg, FA, Eckstein, A, Pearce, SH, Leger, J, et al.2022 European Thyroid Association Guideline for the management of pediatric Graves\u2019 disease. Eur Thyroid J 2022;11: 1.","DOI":"10.1530\/ETJ-21-0073"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Jawwad, M, Ahmed, SA, Zaidi, SMM, Fatmi, SAA, Ashraf, MH, Naeem, S, et al. Long-term outcome of treatments for Graves disease in the children and adolescent population. Endocrine 2023;81: 223\u201330.","DOI":"10.1007\/s12020-023-03371-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Parums, DV. Editorial: review articles, systematic reviews, meta-analysis, and the updated preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines. Med Sci Monit 2021;27: e934475.","DOI":"10.12659\/MSM.934475"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Perzik, SL. Total thyroidectomy in Graves\u2019 disease in children. J Pediatr Surg 1976;11: 191\u20134.","DOI":"10.1016\/0022-3468(76)90286-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Barnes, HV, Blizzard, RM. Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. J Pediatr 1977;91: 313\u201320.","DOI":"10.1016\/S0022-3476(77)80843-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Thompson, NW, Dunn, EL, Freitas, JE, Sisson, JC, Coran, AG, Nishiyama, RH. Surgical treatment of thyrotoxicosis in children and adolescents. J Pediatr Surg 1977;12: 1009\u201318.","DOI":"10.1016\/0022-3468(77)90613-3"},{"key":"11","unstructured":"11. Freitas, JE, Swanson, DP, Gross, MD, Sisson, JC. Iodine-131: optimal therapy for hyperthyroidism in children and adolescents? J Nucl Med 1979;20: 847\u201350."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hamburger, JI. Management of hyperthyroidism in children and adolescents. J Clin Endocrinol Metab 1985;60: 1019\u201324.","DOI":"10.1210\/jcem-60-5-1019"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Rudberg, C, Johansson, H, Akerstr\u00f6m, G, Tuvemo, T, Karlsson, FA. Graves\u2019 disease in children and adolescents. Late results of surgical treatment. Eur J Endocrinol 1996;134: 710\u20135.","DOI":"10.1530\/eje.0.1340710"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Cheetham, TD, Wraight, P, Hughes, IA, Barnes, ND. Radioiodine treatment of Graves\u2019 disease in young people. Horm Res 1998;49: 258\u201362.","DOI":"10.1159\/000023183"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Read, CH, Tansey, MJ, Menda, Y. A 36-year retrospective analysis of the efficacy and safety of radioactive iodine in treating young Graves\u2019 patients. J Clin Endocrinol Metab 2004;89: 4229\u201333.","DOI":"10.1210\/jc.2003-031223"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Sugino, K, Ito, K, Mimura, T, Fukunari, N, Nagahama, M, Ito, K. Surgical treatment of Graves\u2019 disease in children. Thyroid 2004;14: 447\u201352.","DOI":"10.1089\/105072504323150769"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sherman, J, Thompson, GB, Lteif, A, Schwenk, WF, van Heerden, J, Farley, DR, et al. Surgical management of Graves disease in childhood and adolescence: an institutional experience. Surgery 2006;140: 1056\u201361, discussion 1061\u20132.","DOI":"10.1016\/j.surg.2006.07.040"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Chiapponi, C, Stocker, U, Mussack, T, Gallwas, J, Hallfeldt, K, Ladurner, R. The surgical treatment of Graves\u2019 disease in children and adolescents. World J Surg 2011;35: 2428\u201331.","DOI":"10.1007\/s00268-011-1238-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Peroni, E, Angiolini, MR, Vigone, MC, Mari, G, Chiumello, G, Beretta, E, et al. Surgical management of pediatric Graves\u2019 disease: an effective definitive treatment. Pediatr Surg Int 2012;28: 609\u201314.","DOI":"10.1007\/s00383-012-3095-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Breuer, CK, Solomon, D, Donovan, P, Rivkees, SA, Udelsman, R. Effect of patient age on surgical outcomes for Graves\u2019 disease: a case-control study of 100 consecutive patients at a high volume thyroid surgical center. Int J Pediatr Endocrinol 2013;2013: 1.","DOI":"10.1186\/1687-9856-2013-1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Cury, AN, Meira, VT, Monte, O, Marone, M, Scalissi, NM, Kochi, C, et al. Clinical experience with radioactive iodine in the treatment of childhood and adolescent Graves\u2019 disease. Endocr Connect 2012;2: 32\u20137.","DOI":"10.1530\/EC-12-0049"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Elfenbein, DM, Katz, M, Schneider, DF, Chen, H, Sippel, RS. Thyroidectomy for Graves\u2019 disease in children: Indications and complications. J Pediatr Surg 2016;51: 1680\u20133.","DOI":"10.1016\/j.jpedsurg.2016.03.009"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Azizi, F, Amouzegar, A. Management of thyrotoxicosis in children and adolescents: 35 years\u2019 experience in 304 patients. J Pediatr Endocrinol Metab 2018;31: 159\u201365.","DOI":"10.1515\/jpem-2017-0394"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Halada, S, Baran, JA, Isaza, A, Patel, T, Sisko, L, Kazahaya, K, et al. Impact of definitive surgery for Graves\u2019 disease on adolescent disease-specific quality of life and psychosocial functioning. Thyroid 2022;32: 1519\u201328.","DOI":"10.1089\/thy.2022.0334"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Quaglino, F, Bellocchia, AB, Tuli, G, Munarin, J, Matarazzo, P, Cestino, L, et al. Pediatric thyroid surgery: Retrospective analysis on the first 25 pediatric thyroidectomies performed in a reference center for adult thyroid diseases. Front Endocrinol (Lausanne) 2023;14: 1126436.","DOI":"10.3389\/fendo.2023.1126436"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Sheremeta, M, Korchagina, M, Trukhin, A, Nagaeva, E, Bezlepkina, O, Peterkova, V. Thyroid volume is the key predictor of hyperthyroidism remission after radioactive iodine therapy in pediatric patients. Eur J Pediatr 2023;182: 4931\u20137.","DOI":"10.1007\/s00431-023-05153-3"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Trout, AT, Khalatbari, H, Shogbesan, G, Mirza, SK, Sharp, SE, Alazraki, A, et al. Radioiodine treatment of pediatric Graves disease: a multicenter review. Pediatr Radiol 2023;53: 21\u20137.","DOI":"10.1007\/s00247-022-05415-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Chielens, L, Nauwynck, E, Bourgeois, S, Staels, W, Vanbesien, J, Gies, I, et al. A Belgian single centre outcome study of radioiodine treatment in adolescents with Graves\u2019 disease. Sci Rep 2024;14: 31063.","DOI":"10.1038\/s41598-024-82052-z"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. El Kawkgi, OM, Ross, DS, Stan, MN. Comparison of long-term antithyroid drugs versus radioactive iodine or surgery for Graves\u2019 disease: A review of the literature. Clin Endocrinol (Oxf) 2021;95: 3\u201312.","DOI":"10.1111\/cen.14374"}],"container-title":["Clinical Pediatric Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/35\/4\/35_2026-0043\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:40:44Z","timestamp":1790998844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/35\/4\/35_2026-0043\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1297\/cpe.2026-0043","relation":{},"ISSN":["0918-5739","1347-7358"],"issn-type":[{"value":"0918-5739","type":"print"},{"value":"1347-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2026-0043"}}