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Bojesen,              A, Juul,                S,              Gravholt,            CH. Prenatal and            postnatal prevalence of Klinefelter syndrome: a national registry study.            J Clin Endocrinol Metab          2003;88: 622\u20136.","DOI":"10.1210\/jc.2002-021491"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bojesen,              A,              Kristensen,            K, Birkebaek,                NH, Fedder,                J,                Mosekilde,              L, Bennett,                P, et al.            The metabolic syndrome is frequent in Klinefelter\u2019s syndrome and is            associated with abdominal obesity and hypogonadism. Diabetes            Care          2006;29: 1591\u20138.","DOI":"10.2337\/dc06-0145"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Han,              SJ, Kim,                KS, Kim,                W, Kim,                JH, Lee,                YH, Nam,                JS, et al.            Obesity and hyperglycemia in korean men with Klinefelter syndrome: The            Korean Endocrine Society registry. Endocrinol Metab            (Seoul)          2016;31: 598\u2013603.","DOI":"10.3803\/EnM.2016.31.4.598"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bojesen,              A, H\u00f8st,                C,              Gravholt,            CH. Klinefelter\u2019s            syndrome, type 2 diabetes and the metabolic syndrome: the impact of body            composition. Mol Hum Reprod          2010;16: 396\u2013401.","DOI":"10.1093\/molehr\/gaq016"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. O\u2019Connor,                MJ, Snyder,                EA, Hayes,                FJ.            Klinefelter syndrome and diabetes. Curr Diab            Rep          2019;19: 71.","DOI":"10.1007\/s11892-019-1197-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Swerdlow,                AJ,              Higgins, CD,                Schoemaker,              MJ, Wright,                AF, Jacobs,                PA, United            Kingdom Clinical Cytogenetics Group. Mortality in patients            with Klinefelter syndrome in Britain: a cohort study. J Clin            Endocrinol Metab          2005;90: 6516\u201322.","DOI":"10.1210\/jc.2005-1077"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bojesen,              A, Juul,                S,                Birkebaek,              NH, Gravholt,                CH. Morbidity            in Klinefelter syndrome: a Danish register study based on hospital discharge            diagnoses. J Clin Endocrinol Metab          2006;91: 1254\u201360.","DOI":"10.1210\/jc.2005-0697"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Pacenza,              N,              Pasqualini,            T, Gottlieb,                S,                Knoblovits,              P, Costanzo,                PR, Stewart                Usher, J, et            al. Clinical presentation of Klinefelter\u2019s            syndrome: Differences according to age. Int J            Endocrinol          2012;2012: 324835.","DOI":"10.1155\/2012\/324835"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Aksglaede,                L,              Molgaard, C,                Skakkebaek,              NE, Juul,                A. Normal            bone mineral content but unfavourable muscle\/fat ratio in Klinefelter            syndrome. Arch Dis Child          2008;93: 30\u20134.","DOI":"10.1136\/adc.2007.120675"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Bardsley,                MZ,              Falkner, B,                Kowal, K,                Ross,            JL. Insulin            resistance and metabolic syndrome in prepubertal boys with Klinefelter            syndrome. Acta Paediatr          2011;100: 866\u201370.","DOI":"10.1111\/j.1651-2227.2011.02161.x"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Pasquali,                R,                Casimirri,              F,              Cantobelli,            S, Melchionda,                N, Morselli                Labate, AM,                Fabbri, R,              et al. Effect of obesity and body fat            distribution on sex hormones and insulin in men.            Metabolism          1991;40: 101\u20134.","DOI":"10.1016\/0026-0495(91)90199-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Goodman-Gruen,                D,                Barrett-Connor,              E. Sex            differences in the association of endogenous sex hormone levels and glucose tolerance            status in older men and women. Diabetes Care          2000;23: 912\u20138.","DOI":"10.2337\/diacare.23.7.912"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Selice,              R, Caretta,                N, Di                Mambro, A,                Torino, M,                Palego, P,                Ferlin, A,              et al. Prostate volume and growth during            testosterone replacement therapy is related to visceral obesity in Klinefelter            syndrome. Eur J Endocrinol          2013;169: 743\u20139.","DOI":"10.1530\/EJE-13-0488"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Saad,              F, Doros,                G, Haider,                KS, Haider,                A.            Differential effects of 11 years of long-term injectable testosterone            undecanoate therapy on anthropometric and metabolic parameters in hypogonadal men with            normal weight, overweight and obesity in comparison with untreated controls: real-world            data from a controlled registry study. Int J Obes          2020;44: 1264\u201378.","DOI":"10.1038\/s41366-019-0517-7"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Giannoulis,                MG, Martin,                FC, Nair,                KS,              Umpleby, AM,                Sonksen,            P. Hormone            replacement therapy and physical function in healthy older men. Time to talk            hormones? Endocr Rev          2012;33: 314\u201377.","DOI":"10.1210\/er.2012-1002"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Welle,              S,              Jozefowicz,            R, Forbes,                G, Griggs,                RC. Effect of            testosterone on metabolic rate and body composition in normal men and men with muscular            dystrophy. J Clin Endocrinol Metab          1992;74: 332\u20135.          10.1210\/jcem.74.2.1730811.","DOI":"10.1210\/jcem.74.2.1730811"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Chazenbalk,                G, Singh,                P, Irge,                D, Shah,                A, Abbott,                DH,              Dumesic,            DA. Androgens            inhibit adipogenesis during human adipose stem cell commitment to preadipocyte            formation. Steroids          2013;78: 920\u20136.","DOI":"10.1016\/j.steroids.2013.05.001"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Groti,              K, \u017duran,                I, Antoni\u010d,                B,                For\u0161nari\u010d,              L, Pfeifer,                M. The impact            of testosterone replacement therapy on glycemic control, vascular function, and            components of the metabolic syndrome in obese hypogonadal men with type 2            diabetes. Aging Male          2018;21: 158\u201369.","DOI":"10.1080\/13685538.2018.1468429"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Zitzmann,                M.            Testosterone deficiency, insulin resistance and the metabolic            syndrome. Nat Rev Endocrinol          2009;5: 673\u201381.","DOI":"10.1038\/nrendo.2009.212"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Li,                SY, Zhao,                YL, Yang,                YF, Wang,                X, Nie,                M, Wu,                XY, et al.            Metabolic effects of testosterone replacement therapy in patients with            type 2 diabetes mellitus or metabolic syndrome: A meta-analysis.            Int J Endocrinol          2020;2020: 4732021.","DOI":"10.1155\/2020\/4732021"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Bojesen,              A, Gravholt,                CH.            Klinefelter syndrome in clinical practice. Nat            Clin Pract Urol          2007;4: 192\u2013204.","DOI":"10.1038\/ncpuro0775"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Mehta,              A, Clearman,                T, Paduch,                DA. Safety            and efficacy of testosterone replacement therapy in adolescents with Klinefelter            syndrome. J Urol          2014;191(Suppl):            1527\u201331.","DOI":"10.1016\/j.juro.2013.09.015"},{"key":"23","unstructured":"23. Rogol,              AD,              Tartaglia,            N. Considerations            for androgen therapy in children and adolescents with Klinefelter syndrome (47,            XXY). 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