{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:22:08Z","timestamp":1783560128884,"version":"3.55.0"},"reference-count":16,"publisher":"Japanese Society for Pediatric Endocrinology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr Endocrinol"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1297\/cpe.30.79","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T18:08:11Z","timestamp":1617386891000},"page":"79-84","source":"Crossref","is-referenced-by-count":7,"title":["Investigation of TSH receptor blocking antibodies in childhood-onset atrophic          autoimmune thyroiditis"],"prefix":"10.1297","volume":"30","author":[{"given":"Keisuke","family":"Nagasaki","sequence":"first","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic              Regulation and Development, Niigata University Graduate School of Medicine and Dental              Science, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akie","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hokkaido University School of              Medicine, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tsuchiura Kyodo General              Hospital, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hotaka","family":"Kamasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Sapporo Medical University              School of Medicine,\u00a0Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu              University School of Medicine, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tohoku University School of              Medicine, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dokkyo Medical University              School of Medicine, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gunma University Graduate              School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Akita University Graduate              School of Medicine, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Asahikawa Medical University,              Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kashimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tokyo Medical and Dental              University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jichi Medical University,              Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"125","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Matsuura,                N, Konishi,                J, Yuri,                K, Harada,                S, Fujieda,                K, Nohara,                Y, et al.            Comparison of atrophic and goitrous auto-immune thyroiditis in children:            clinical, laboratory and TSH-receptor antibody studies. Eur J            Pediatr          1990;149: 529\u201333.","DOI":"10.1007\/BF01957685"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Takasu,              N, Yamada,                T,              Katakura, M,                Yamauchi,            K, Shimizu,                Y,              Ishizuki,            Y. Evidence for            thyrotropin (TSH)-blocking activity in goitrous Hashimoto\u2019s thyroiditis with assays            measuring inhibition of TSH receptor binding and TSH-stimulated thyroid adenosine            3\u2032,5\u2032-monophosphate responses\/cell growth by immunoglobulins. J            Clin Endocrinol Metab          1987;64: 239\u201345.","DOI":"10.1210\/jcem-64-2-239"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Chiovato,                L, Vitti,                P, Santini,                F, Lopez,                G, Mammoli,                C, Bassi,                P, et al.            Incidence of antibodies blocking thyrotropin effect in vitro in patients            with euthyroid or hypothyroid autoimmune thyroiditis. J Clin            Endocrinol Metab          1990;71: 40\u20135.","DOI":"10.1210\/jcem-71-1-40"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Nakagawa,                Y, Toya,                K, Nasuda,                K, Iijima,                S, Kubota,                A, Natsume,                H, et al.            A boy with atrophic thyroiditis of prepubertal onset, who was positive            for TSH-binding inhibitor immunoglobulins. Acta Paediatr            Jpn          1995;37: 405\u20138.","DOI":"10.1111\/j.1442-200X.1995.tb03343.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kawahara,                K,                Tsukimoto,              I, Yokoya,                S. Atrophic            autoimmune thyroiditis with positive thyroid stimulation blocking antibody in a            prepubertal boy. Clin Pediatr Endocrinol          2000;9: 105\u201311.","DOI":"10.1297\/cpe.9.105"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Inamo,              Y. A 5-year-old            boy with atrophic autoimmune thyroiditis caused by thyroid-stimulation blocking            antibodies. J Pediatr Endocrinol Metab          2011;24: 591\u20134.","DOI":"10.1515\/jpem.2011.193"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Rivkees,                SA, Bode,                HH,                Crawford,              JD. Long-term            growth in juvenile acquired hypothyroidism: the failure to achieve normal adult            stature. N Engl J Med          1988;318: 599\u2013602.","DOI":"10.1056\/NEJM198803103181003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yasumoto,                M, Inoue,                H, Ohashi,                I, Shibuya,                H, Onishi,                T. Simple new            technique for sonographic measurement of the thyroid in neonates and small            children. J Clin Ultrasound          2004;32: 82\u20135.","DOI":"10.1002\/jcu.10234"},{"key":"9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/thy.2000.10.891","volume":"10","year":"2000","unstructured":"9. Takasu,              N, Yamashiro,                K, Komiya,                I, Ochi,                Y, Sato,                Y, Nagata,                A. Remission            of Graves\u2019 hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody            and thyrotropin-binding inhibitor immunoglobulin during antithyroid drug            treatment. Thyroid          2000;10: 891\u20136.","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Takasu,              N,              Matsushita,            M. Changes of            TSH-stimulation blocking antibody (TSBAb) and thyroid stimulating antibody (TSAb) over            10 years in 34 TSBAb-positive patients with hypothyroidism and in 98 TSAb-positive            Graves\u2019 patients with hyperthyroidism: reevaluation of TSBAb and TSAb in            TSH-receptor-antibody (TRAb)-positive patients. J Thyroid            Res          2012;2012: 182176.","DOI":"10.1155\/2012\/182176"},{"key":"11","unstructured":"11. Kasagi,              K, Hiruma,                M,              Watanabe, N,                Yoshimura,              JN. Usefulness            and limitation of TSBAb assessment-clinical application by newly developed Yamasa assay            kit. Journal of the Japanese Thyroid Association.          2018;9: 172\u20139(In            Japanese)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kasagi,              K, Konishi,                J, Arai,                K, Misaki,                T, Iida,                Y, Endo,                K, et al.            A sensitive and practical assay for thyroid-stimulating antibodies using            crude immunoglobulin fractions precipitated with polyethylene glycol.            J Clin Endocrinol Metab          1986;62: 855\u201362.","DOI":"10.1210\/jcem-62-5-855"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Feingold,                SB, Smith,                J, Houtz,                J,              Popovsky, E,                Brown,            RS. Prevalence            and functional significance of thyrotropin receptor blocking antibodies in children and            adolescents with chronic lymphocytic thyroiditis. J Clin            Endocrinol Metab          2009;94: 4742\u20138.","DOI":"10.1210\/jc.2009-1243"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Diana,              T, Li,                Y, Olivo,                PD,              Lackner, KJ,                Kim, H,                Kanitz, M,              et al. Analytical performance and            validation of a bioassay for thyroid-blocking antibodies.            Thyroid          2016;26: 734\u201340.","DOI":"10.1089\/thy.2015.0447"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Diana,              T, Olivo,                PD, Kahaly,                GJ.            Thyrotropin receptor blocking antibodies. Horm            Metab Res          2018;50: 853\u201362.","DOI":"10.1055\/a-0723-9023"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Takasu,              N, Yamada,                T, Takasu,                M, Komiya,                I,              Nagasawa, Y,                Asawa, T,              et al. Disappearance of            thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in            autoimmune thyroiditis. N Engl J Med          1992;326: 513\u20138.","DOI":"10.1056\/NEJM199202203260803"}],"container-title":["Clinical Pediatric Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/30\/2\/30_2020-0054\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T23:58:58Z","timestamp":1617407938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpe\/30\/2\/30_2020-0054\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1297\/cpe.30.79","relation":{},"ISSN":["0918-5739","1347-7358"],"issn-type":[{"value":"0918-5739","type":"print"},{"value":"1347-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}