{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:12:09Z","timestamp":1764936729949,"version":"3.30.1"},"reference-count":27,"publisher":"Medknow","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":342,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Pacific Journal of Tropical Biomedicine"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.12980\/apjtb.4.2014c1049","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T05:15:11Z","timestamp":1400649311000},"page":"S455-S459","source":"Crossref","is-referenced-by-count":11,"special_numbering":"S1","title":["In vitro and in silico antidiabetic activity of pyran ester derivative isolated from Tragia cannabina"],"prefix":"10.4103","volume":"4","author":[{"given":"Vaiyapuri","family":"Sivajothi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi Shirur","family":"Dakappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2581","reference":[{"key":"10.12980\/APJTB.4.2014C1049_bib1","series-title":"The wealth of India. Vol. X: A dictionary of Indian raw materials and industrial products","first-page":"272","author":"Council of Scientific & Industrial Research","year":"1998"},{"key":"10.12980\/APJTB.4.2014C1049_bib2","series-title":"Indian materia medica","first-page":"1226","author":"Nadkarni","year":"1976"},{"key":"10.12980\/APJTB.4.2014C1049_bib3","first-page":"313","article-title":"Plants used by the ethnic people of Krishna district, Andhra Pradesh","volume":"9","author":"Reddy","year":"2010","journal-title":"Indian J Tradit Knowl"},{"key":"10.12980\/APJTB.4.2014C1049_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/jmf.2006.030","article-title":"Antihyperglycemic property of Tragia cannabina in streptozotocin-induced diabetic rats","volume":"10","author":"Sivajothi","year":"2007","journal-title":"J Med Food"},{"key":"10.12980\/APJTB.4.2014C1049_bib5","series-title":"Human medicinal agents from plants, ACS symposium series 534","first-page":"48","author":"Balandrin","year":"1993"},{"key":"10.12980\/APJTB.4.2014C1049_bib6","series-title":"Indian medicinal plants","first-page":"2190","author":"Kirtikar","year":"2002"},{"key":"10.12980\/APJTB.4.2014C1049_bib7","series-title":"Human medicinal agents from plants, ACS symposium series 534","first-page":"2","author":"Balandrin","year":"1993"},{"key":"10.12980\/APJTB.4.2014C1049_bib8","first-page":"479","article-title":"Evaluation of acute and subacute toxicity of alcoholic extract of the roots of Tragia cannabina in rats","volume":"3","author":"Patel","year":"2012","journal-title":"Int J Pharm Sci Res"},{"key":"10.12980\/APJTB.4.2014C1049_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00003495-200060010-00006","article-title":"A rational approach to drug therapy of type 2 diabetes mellitus","volume":"60","author":"Chehade","year":"2000","journal-title":"Drugs"},{"key":"10.12980\/APJTB.4.2014C1049_bib10","first-page":"144","article-title":"Epidemiology of diabetes in India-current perspective and future projections","volume":"100","author":"Pradeepa","year":"2002","journal-title":"J Indian Med Assoc"},{"key":"10.12980\/APJTB.4.2014C1049_bib11","first-page":"424","article-title":"Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: Its implication in plant growth and abiotic stress tolerance","volume":"88","author":"Kavi Kishor","year":"2005","journal-title":"Curr Sci"},{"key":"10.12980\/APJTB.4.2014C1049_bib12","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev"},{"key":"10.12980\/APJTB.4.2014C1049_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0968-0004(98)01340-1","article-title":"Dealing with energy demand: the AMP-activated protein kinase","volume":"24","author":"Kemp","year":"1999","journal-title":"Trends Biochem Sci"},{"key":"10.12980\/APJTB.4.2014C1049_bib14","first-page":"611","article-title":"Mammalian AMP-activated protein kinase subfamily","volume":"271","author":"Stapleton","year":"1996","journal-title":"J BiolChem"},{"key":"10.12980\/APJTB.4.2014C1049_bib15","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1113\/jphysiol.2010.194811","article-title":"Exercise-induced TBC1D1 Ser237 phosphorylation and 14\u20133-3 protein binding capacity in human skeletal muscle","volume":"588","author":"Fr\u00f8sig","year":"2010","journal-title":"J Physiol"},{"key":"10.12980\/APJTB.4.2014C1049_bib16","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1194\/jlr.R025882","article-title":"AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases","volume":"53","author":"Srivastava","year":"2012","journal-title":"J Lipid Res"},{"key":"10.12980\/APJTB.4.2014C1049_bib17","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.chembiol.2012.08.019","article-title":"AMP-activated protein kinase: a target for drugs both ancient and modern","volume":"19","author":"Hardie","year":"2012","journal-title":"Chem Biol"},{"key":"10.12980\/APJTB.4.2014C1049_bib18","series-title":"Phytochemical methods","first-page":"49","author":"Harborne","year":"1973"},{"key":"10.12980\/APJTB.4.2014C1049_bib19","first-page":"11","article-title":"Effect of Nicotinamide on experimental induced diabetes","volume":"8","author":"Alenzi","year":"2009","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.12980\/APJTB.4.2014C1049_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1248\/bpb.28.151","article-title":"Toxic interactions between fluconazole and disopyramide in chick embryos","volume":"28","author":"Yoshiyama","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.12980\/APJTB.4.2014C1049_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1900\/RDS.2011.8.245","article-title":"Modeling chick to assess diabetes pathogenesis and treatment","volume":"8","author":"Datar","year":"2011","journal-title":"Rev Diabet Stud"},{"issue":"17","key":"10.12980\/APJTB.4.2014C1049_bib22","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3923\/pjbs.2013.844.851","article-title":"Antidiabetic activity of methanolic extract of Hiptage bengalensis leaves in alloxan induced diabetic models","volume":"16","author":"Maheshwari","year":"2013","journal-title":"Pak J Biol Sci"},{"key":"10.12980\/APJTB.4.2014C1049_bib23","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1093\/nar\/gkg512","article-title":"CASTp: computed atlas of surface topography of proteins","volume":"31","author":"Binkowski","year":"2003","journal-title":"Nucleic Acid Res"},{"key":"10.12980\/APJTB.4.2014C1049_bib24","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s00044-011-9614-4","article-title":"Antibacterial and molecular docking studies of entagenic acid, a bioactive principle from seed kernel of Entada pursaetha DC","volume":"21","author":"Vidya","year":"2012","journal-title":"Med Chem Res"},{"key":"10.12980\/APJTB.4.2014C1049_bib25","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1007\/s00044-012-0295-4","article-title":"Isolation, characterization, antibacterial, antihelminthic, and In silico studies of polyprenol from Kirganelia reticulata Baill","volume":"22","author":"Shruthi","year":"2013","journal-title":"Med Chem Res"},{"key":"10.12980\/APJTB.4.2014C1049_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jmgm.2012.10.009","article-title":"Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.)","volume":"39","author":"Annapurna","year":"2013","journal-title":"J Mol Graph Modell"},{"key":"10.12980\/APJTB.4.2014C1049_bib27","first-page":"34","article-title":"Characterization in silico of flavonoids biosynthesis in Theobroma cacao L","volume":"1","author":"Rodriguez","year":"2011","journal-title":"Network Biol"}],"container-title":["Asian Pacific Journal of Tropical Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2221169115303105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2221169115303105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T19:24:42Z","timestamp":1514921082000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2221169115303105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":27,"alternative-id":["S2221169115303105"],"URL":"https:\/\/doi.org\/10.12980\/apjtb.4.2014c1049","relation":{},"ISSN":["2221-1691"],"issn-type":[{"type":"print","value":"2221-1691"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}