{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:53:34Z","timestamp":1762606414239,"version":"3.30.1"},"reference-count":27,"publisher":"Medknow","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":311,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Pacific Journal of Tropical Biomedicine"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.12980\/apjtb.4.2014c207","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T01:46:56Z","timestamp":1399945616000},"page":"480-485","source":"Crossref","is-referenced-by-count":15,"title":["Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4\u2013induced liver damage in rats"],"prefix":"10.4103","volume":"4","author":[{"given":"James Dorcas","family":"Bolanle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadejo Olubukola","family":"Adetoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallau Abdullahi","family":"Balarabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owolabi Olumuyiwa","family":"Adeyemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2581","reference":[{"key":"10.12980\/APJTB.4.2014C207_bib1","first-page":"1318","article-title":"A review of natural products with hepatoprotective activity","volume":"4","author":"Adewusi","year":"2010","journal-title":"J Med Plants Res"},{"key":"10.12980\/APJTB.4.2014C207_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/hep.21347","article-title":"Gobal challenges in liver disease","volume":"44","author":"Williams","year":"2006","journal-title":"Hepatology"},{"key":"10.12980\/APJTB.4.2014C207_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3742\/OPEM.2010.10.2.111","article-title":"Hepatoprotective activity of Nyctanthes arbor-tristis (L.)","volume":"10","author":"Wagh","year":"2010","journal-title":"Orient Pharm Exp Med"},{"key":"10.12980\/APJTB.4.2014C207_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.devcel.2010.01.011","article-title":"Organogenesis and development of the liver","volume":"18","author":"Si-Tayeb","year":"2010","journal-title":"Dev Cell"},{"key":"10.12980\/APJTB.4.2014C207_bib5","first-page":"51","article-title":"Aqueous extract of Flacourtia indica prevents carbon tetrachloride induced hepatotoxicity in rat","volume":"6","author":"Gnanaprakash","year":"2010","journal-title":"Int J Biol Life Sci"},{"key":"10.12980\/APJTB.4.2014C207_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2008.12.006","article-title":"Carbon tetrachloride induced nephrotoxicity in rats: protective role of Digera muricata","volume":"122","author":"Khan","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"10.12980\/APJTB.4.2014C207_bib7","first-page":"257","article-title":"Hepatoprotective activity of six polyherbal formulation in CCl4 induced liver toxicity in mice","volume":"47","author":"Girish","year":"2009","journal-title":"Indian J Exp Biol"},{"key":"10.12980\/APJTB.4.2014C207_bib8","first-page":"1","article-title":"Typical uses of certain common and uncommon plants","volume":"23","author":"Hota","year":"2003","journal-title":"Anc Sci Life"},{"key":"10.12980\/APJTB.4.2014C207_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3923\/rjmp.2011.491.499","article-title":"Bauhinia purpurea Linn.: a review of its ethnobotany, phytochemical and pharmacological profile","volume":"5","author":"Kumar","year":"2011","journal-title":"Res J Med Plant"},{"key":"10.12980\/APJTB.4.2014C207_bib10","first-page":"19","article-title":"Effects of Vitex doniana stem bark on blood pressure","volume":"1","author":"Olusola","year":"1997","journal-title":"Nig J Nat Prod Med"},{"issue":"2","key":"10.12980\/APJTB.4.2014C207_bib11","first-page":"177","article-title":"Comparative in vitro trypanocidal activities of petroleum ether, chloroform, methanol, and aqueous extracts of some Nigerian savannah plants","volume":"4","author":"Atawodi","year":"2005","journal-title":"Afri J Biotechnol"},{"issue":"5","key":"10.12980\/APJTB.4.2014C207_bib12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S2221-1691(13)60083-0","article-title":"In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats","volume":"3","author":"Adetoro","year":"2013","journal-title":"Asian Pac J Trop Biomed"},{"issue":"1","key":"10.12980\/APJTB.4.2014C207_bib13","first-page":"1","article-title":"Effects of aqueous extracts (leaves and stem) of Vitex doniana on carbon tetrachloride induced liver injury in rats","volume":"1","author":"James","year":"2010","journal-title":"Br J Pharmacol Toxicol"},{"key":"10.12980\/APJTB.4.2014C207_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01234480","article-title":"A new approach to practical acute toxicity testing","volume":"54","author":"Lorke","year":"1983","journal-title":"Arch Toxicol"},{"key":"10.12980\/APJTB.4.2014C207_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2007-1007105","article-title":"Cytokines and fibrogenesis","volume":"9","author":"Friedman","year":"1999","journal-title":"Semin Liver Dis"},{"issue":"1\u20132","key":"10.12980\/APJTB.4.2014C207_bib16","first-page":"9","article-title":"Effect of substituting pumpkin seed protein isolate for caseinon serum liver enzymes, lipid profile and antioxidant enzymes in CCl4-intoxicated rats","volume":"3","author":"Mohamed","year":"2009","journal-title":"Adv Biol Res"},{"issue":"4","key":"10.12980\/APJTB.4.2014C207_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ptr.1685","article-title":"Effect of pumpkin seed (Cucurbita Pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low protein fed rats","volume":"19","author":"Nkosi","year":"2005","journal-title":"Phytother Res"},{"issue":"2","key":"10.12980\/APJTB.4.2014C207_bib18","first-page":"51","article-title":"Hypolipidemic activity of Cyperous rotundus on CCl4 induced dyslipidemia in rats","volume":"2","author":"Dominic Amalraj","year":"2012","journal-title":"Asian J Pharm Technol"},{"key":"10.12980\/APJTB.4.2014C207_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.etp.2010.09.009","article-title":"Antioxidant effects of Citharexylum spinosum in CCl4 induced nephrotoxicity in rat","volume":"64","author":"Khan","year":"2012","journal-title":"Exp Toxicol Pathol"},{"issue":"4","key":"10.12980\/APJTB.4.2014C207_bib20","first-page":"21","article-title":"Antihepatotoxic effect of Elephantopus scaber L. on carbon tetrachloride-induced hepatotoxicity in rats","volume":"4","author":"Battu","year":"2012","journal-title":"Recent Res Sci Technol"},{"issue":"26","key":"10.12980\/APJTB.4.2014C207_bib21","first-page":"1958","article-title":"Protective effect of green tea on CCl4 induced hepatoxicity in experimental rats","volume":"6","author":"Shahid","year":"2012","journal-title":"African J Pharm Pharmacol"},{"key":"10.12980\/APJTB.4.2014C207_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3797\/scipharm.0803-16","article-title":"Hepatoprotective and antioxidant effects of Pisonia aculeata L. against CCl4-induced hepatic damage in rats","volume":"76","author":"Palanivel","year":"2008","journal-title":"Sci Pharm"},{"issue":"8","key":"10.12980\/APJTB.4.2014C207_bib23","first-page":"4006","article-title":"Biochemical and histopathological studies of Butea monosperma (Lam) Taub leaves on paracetamol induced hepatotoxicity in albino rats","volume":"5","author":"Chavan Sandeep","year":"2012","journal-title":"J Pharm Res"},{"issue":"5","key":"10.12980\/APJTB.4.2014C207_bib24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4103\/0253-7613.84973","article-title":"Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats","volume":"43","author":"Anusha","year":"2011","journal-title":"Indian J Pharmacol"},{"key":"10.12980\/APJTB.4.2014C207_bib25","first-page":"641","article-title":"Protective effects of curcumin and vitamin E on carbon tetrachloride-induced nephrotoxicity in rats","volume":"11","author":"Venkatanarayana","year":"2012","journal-title":"EXCLI J"},{"issue":"90","key":"10.12980\/APJTB.4.2014C207_bib26","doi-asserted-by":"crossref","first-page":"15702","DOI":"10.5897\/AJB11.3876","article-title":"Hepatoprotective effect of basil (Ocimum Basilicum L.) on CCl4-induced liver fibrosis in rats","volume":"11","author":"Yacout","year":"2012","journal-title":"Afr J Biotechnol"},{"issue":"30","key":"10.12980\/APJTB.4.2014C207_bib27","first-page":"2255","article-title":"Antioxidant and hepatoprotective effects of oxalis corniculata against carbon tetrachloride (CCl4) induced injuries in rats","volume":"6","author":"Khan","year":"2012","journal-title":"Afr J Pharm Pharmacol"}],"container-title":["Asian Pacific Journal of Tropical Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2221169115302264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2221169115302264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T19:22:22Z","timestamp":1514920942000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2221169115302264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S2221169115302264"],"URL":"https:\/\/doi.org\/10.12980\/apjtb.4.2014c207","relation":{},"ISSN":["2221-1691"],"issn-type":[{"type":"print","value":"2221-1691"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}