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The aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein, and its cognitive implications in the development of AD. It was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198, Ser199, Ser202, Thr205, Ser396 and Ser404. Contact with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta, and protein phosphatase-2A. Moreover, it altered the expression of the microtubule associated protein tau gene, and changed levels of intracellular calcium. These changes affected tau protein phosphorylation and neuroinflammation, and also increased oxidative stress. In addition, the exposed subjects had poor level of performance in tests that involved evaluation of novelty, as test on verbal, non-verbal, spatial memory, attention, and problem-solving skills. <\/jats:p>","DOI":"10.12998\/wjcc.v11.i24.5797","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:26:33Z","timestamp":1692735993000},"page":"5797-5803","source":"Crossref","is-referenced-by-count":3,"title":["Papillary thyroid carcinoma with nodular fasciitis-like stroma - an unusual variant with distinctive histopathology: A case report"],"prefix":"10.12998","volume":"11","author":[{"given":"Jun","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10090723"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyac011"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opz100"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/1066896915570362"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.3.309"},{"key":"B6","unstructured":"Ma X, Xia C, Liu H, Zhu W. 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