{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T05:15:57Z","timestamp":1701839757400},"reference-count":13,"publisher":"Baishideng Publishing Group Inc.","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>A case of neuromyelitis optica spectrum disorder (NMOSD) with positive cerebrospinal fluid (CSF) anti-aquaporin-4 antibody (AQP4-IgG) and anti-glial fibrillary acidic protein IgG (GFAP-IgG) at the time of relapse was reported. The exact roles of GFAP-IgG in NMOSD are not fully understood and are the subject of ongoing research. This study revealed the possible connection between GFAP-IgG and the occurrence or development of diseases.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 19-year-old woman was admitted to the hospital due to a constellation of symptoms, including dizziness, nausea, and vomiting that commenced 1 year prior, reoccurred 2 mo ago, and were accompanied by visual blurring that also began 2 mo ago. Additionally, she presented with slurred speech and ptosis, both of which emerged 1 mo ago. Notably, her symptoms deteriorated 10 d prior to admission, leading to the onset of arm and leg weakness. During hospitalization, magnetic resonance imaging showed high T2-fluid attenuated inversion recovery signals, and slightly high and equal diffusion-weighted imaging signals. The serum antibody of AQP4-IgG tested positive at a dilution of 1:100. CSF antibody testing showed positive results for GFAP-IgG at a dilution of 1:10 and AQP4-IgG at a dilution of 1:32. Based on these findings, the patient was diagnosed with NMOSD. She received intravenous methylprednisolone at a daily dose of 500 mg for 5 d, followed by a tapering-off period. Afterward, the rate of reduction was gradually slowed down and the timely use of immunosuppressants was implemented.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>The CFS was slightly GFAP-IgG-positive during the relapse period, which can aid in the diagnosis and treatment of the disease.<\/jats:p>","DOI":"10.12998\/wjcc.v11.i34.8192","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T02:32:15Z","timestamp":1701829935000},"page":"8192-8199","source":"Crossref","is-referenced-by-count":0,"title":["Anti-glial fibrillary acidic protein antibody and anti-aquaporin-4 antibody double-positive neuromyelitis optica spectrum disorder: A case report"],"prefix":"10.12998","volume":"11","author":[{"given":"Ting-Yu","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Tong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jv","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002366"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/83679"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.150698"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(95)00152-r"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5863-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30392-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102202"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2148657"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211054952"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24881"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001052"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v11\/i34\/8192.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v11\/i34\/8192.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T02:33:33Z","timestamp":1701830013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v11\/i34\/8192.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":13,"journal-issue":{"issue":"34"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v11.i34.8192","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,6]]}}}