{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:54:38Z","timestamp":1718783678722},"reference-count":27,"publisher":"Baishideng Publishing Group Inc.","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Brain metastases (BM) are very rare in gastric adenocarcinoma (GaC), and patients with BMs have a higher mortality rate due to stronger tumor aggressiveness. However, its pathogenesis remains unclear. Genetic testing revealed cellular-mesenchymal epithelial transition factor receptor (MET) amplification. Therefore, treatment with savolitinib, a small molecule inhibitor of c-Met, was selected.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back pain. Cerebellar and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine therapy. The patient experienced frequent generalized seizures and persistent drowsiness in the emergency department. Genetic testing of cerebrospinal fluid and peripheral blood revealed increased MET amplification. After discussing treatment options with the patient, savolitinib tablets were administered. After a month of treatment, the intracranial lesions shrank considerably.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>BM is very rare in advanced GaC, especially in meningeal cancer, that is characterized by rapid disease deterioration. There are very few effective treatment options available; however, technological breakthroughs in genomics have provided a basis for personalized treatment. Furthermore, MET amplification may be a key driver of BM in gastric cancer; however, this conclusion requires further investigation.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i15.2636","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:34:01Z","timestamp":1715657641000},"page":"2636-2641","source":"Crossref","is-referenced-by-count":1,"title":["Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis: A case report"],"prefix":"10.12998","volume":"12","author":[{"given":"Zhi-Yun","family":"Weng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin-Kan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Jia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.203"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/17588359211027837"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00175-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.8585"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-19-0455"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1758834011423402"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194708"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1080"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0377-z"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14382"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084502"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0471-6"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.897681"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-018-2798-4"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1098"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3541"},{"key":"B19","unstructured":"Cinar P, Calkins SM, Venook AP, Kelley RK. A case series of patients with HER2-overexpressed primary metastatic gastroesophageal adenocarcinoma. Anticancer Res 2014; 34: 7357-7360"},{"key":"B20","unstructured":"Katayanagi S, Arai K, Iwasaki Y, Takahashi K, Yamaguchi T, Matsumoto H, Miyamoto H. [A case of liver metastases from gastric cancer successfully treated with induced hypertensive chemotherapy]. Gan To Kagaku Ryoho 2003; 30: 1722-1725"},{"key":"B21","unstructured":"Kitayama Y, Yoden Y, Okamoto N. [A case of effective paclitaxel therapy for gastric cancer with brain metastasis]. Gan To Kagaku Ryoho 2006; 33: 981-984"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-818"},{"key":"B23","unstructured":"Rino Y, Sekino Y, Yamada T, Nakayama T, Arai H, Kanari M, Saeki H, Yukawa N, Wada N, Masuda M, Higashida T, Imada T. [Irinotecan+cisplatin and irradiation are effective for brain metastases of gastric cancer--two case reports]. Gan To Kagaku Ryoho 2007; 34: 1095-1098"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2019.02.048"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3906-0"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50040"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2176\/nmccrj.cr.2018-0175"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2636.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2636.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:35:56Z","timestamp":1715657756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2636.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":27,"journal-issue":{"issue":"15"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i15.2636","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,26]]}}}