{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:11:40Z","timestamp":1754485900645},"reference-count":12,"publisher":"Baishideng Publishing Group Inc.","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Multiple primary carcinomas (MPCs) are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same individual. Synchronous MPCs are rarer than solitary cancers or metachronous MPCs. Accurate diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these cases.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 64-year-old patient presented with dysphagia, without obvious cause. A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory results. After multi-disciplinary consultations, combination chemotherapy (a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14) and esophageal cancer radiotherapy were initiated. Based on the results of genetic testing, we switched to a regimen of leucovorin + fluorouracil + oxaliplatin and cetuximab regimen for 8 cycles. Subsequently, capecitabine and bevacizumab were administered until the most recent follow-up, at which the tumor remained stable.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Successful cetuximab chemotherapy treatment provides a reference for the non-operative and homogeneous treatment of different pathological types of synchronous MCPs.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i15.2649","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:34:01Z","timestamp":1715657641000},"page":"2649-2654","source":"Crossref","is-referenced-by-count":2,"title":["Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma: A case report"],"prefix":"10.12998","volume":"12","author":[{"given":"Xin-Xin","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Quan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"B1","unstructured":"Copur MS, Manapuram S. Multiple Primary Tumors Over a Lifetime. Oncology (Williston Park) 2019; 33: 629384"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v15.i12.2049"},{"key":"B3","unstructured":"Warren S, Gates O. Multiple primary malignant tumors: A survey of the literature and statistical study. Am J Cancer 1932; 16: 1358-1414"},{"key":"B4","unstructured":"Cai YL.   The clinical characteristics and prognosis of 234 multiple primary cancer patients. Ph.D. Dissertation, College of Medicine, Zhejiang University. 2018. Available from: https:\/\/kns.cnki.net\/kcms2\/article\/abstract?v=Dl4MPbsAiWcWfY1btBpXwon0GWs-VxBEj_37ZWm1q_t3uH8sc0Wf3CRY5P8ml1XcPyCEDW2us9-bcEm85ynmrOOMQ8D7wZNipvgiEuAToM0SxI3-eDAiVH1yGarm0vZiTaoUWQn7XLQ=&uniplatform=NZKPT&flag=copy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7525-y"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002118"},{"key":"B7","unstructured":"Su XY, Yan Y, Jiang Q, Xia JH. [Overall survival analysis of double primary cancer patients with esophageal cancer as the first primary cancer]. Zhonghua Xiaohuabing Yu Yingxiang Zazhi 2021; 11: 121-125"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000172"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-018-0641-9"},{"key":"B10","unstructured":"National Comprehensive Cancer Network.   National Comprehensive Cancer Network guidelines: Colon cancer. Version 1. 2022"},{"key":"B11","unstructured":"Cheng G, Jiang XD, Zhang HP, Yang P, Liu H, Gu KS. [Clinical observation of 54 cases of non-surgical esophageal cancer treated with capecitabine rhythm chemotherapy combined with concurrent dose modulated radiation therapy]. Shandong Yiyao 2017; 57: 87-89"},{"key":"B12","unstructured":"Cheng XY, Wu H, Zhang RR, Sun XM, Yan ZM, Liu X, Chen YS. [Prognostic analysis of 307 cases of stage II-III esophageal cancer treated with concurrent radiotherapy and chemotherapy]. Zhonghua Fangshe Zhongliuxue Zazhi 2018; 27: 140-144"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2649.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2649.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:36:06Z","timestamp":1715657766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i15\/2649.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":12,"journal-issue":{"issue":"15"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i15.2649","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,26]]}}}