{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:22:27Z","timestamp":1719620547766},"reference-count":24,"publisher":"Baishideng Publishing Group Inc.","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Stromal cell derived factor-1 (SDF-1) plays a pivotal role in the recruitment of stem cells to injured livers. However, the changes of SDF-l in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) have yet to be elucidated.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To study the SDF-1 changes in patients with HBV-related ACLF.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>30 patients with HBV-related ACLF, 27 patients with chronic hepatitis B and 20 healthy individuals are involved in our study. The SDF-l mRNA expression in liver tissue was detected by quantitative real-time polymerase chain reaction. Immunohistochemical staining was performed to illustrate the expression of SDF-l, CXC receptor 4 (CXCR4) and Ki67. The serum SDF-l concentrations were also detected by enzyme-linked immunosorbent assays.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The expression of SDF-1 mRNA from ACLF patients was remarkably higher than that from other patients (both P  &lt; 0.05). The expression of SDF-l, CXCR4 and Ki67 from ACLF were the highest among the three groups (all P  &lt; 0.01). The serum SDF-l levels in ACLF patients were significantly lower than that in other patients (both P  &lt; 0.01). Moreover, in ACLF patients, the serum SDF-1 Levels were positively correlated with serum total bilirubin and international normalized ratio. In addition, the serum SDF-l levels in survival were significantly lower compared with the non-survivals (P  &lt; 0.05). The area under the curve for the serum SDF-1 level in predicting 28-d mortality was 0.722 (P  &lt; 0.05).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This study provides the SDF-1 changes in patients with HBV-related ACLF. The SDF-1 Level at admission may serve as a promising prognostic marker for predicting short-term prognosis.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i19.3845","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T17:15:24Z","timestamp":1719594924000},"page":"3845-3853","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic role of the stromal cell derived factor-1 in patients with hepatitis B virus-related acute-on-chronic liver failure"],"prefix":"10.12998","volume":"12","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i2.232"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.07.036"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297919030015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1243220"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131729"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.615264"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06366-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02932-y"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11361"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7150\/jca.20935"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.086"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.716842"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3254"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720929992"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20-0435"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0226"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002877"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001596"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2015.08.005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015212"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.63"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i19\/3845.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i19\/3845.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T17:17:48Z","timestamp":1719595068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i19\/3845.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,6]]},"references-count":24,"journal-issue":{"issue":"19"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i19.3845","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,6]]}}}