{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:21:11Z","timestamp":1729657271639,"version":"3.28.0"},"reference-count":17,"publisher":"Baishideng Publishing Group Inc.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Tuberculosis is a chronic infectious disease and an important public health problem. Despite progress in controlling tuberculosis, the incidence of tuberculosis in China is still very high, with 895000 new cases annually. This case report describes the investigation of a case of severe disseminated tuberculosis in a young adult with normal immune function, conducted to ascertain why a Mycobacterium tuberculosis  (M. tuberculosis ) strain caused such severe disease.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A previously healthy 28-year-old woman presented to our hospital with a 1-month history of fever and fatigue. She was diagnosed with severe disseminated pulmonary tuberculosis, spinal tuberculosis with paravertebral abscesses, and tuberculous meningitis. M. tuberculosis  was isolated from bronchoalveolar lavage fluid. She was treated with standard antituberculous therapy and underwent debridement, bone graft, and internal fixation surgery for spinal tuberculosis. She responded to therapy and regained her ability to walk following the surgery. We analysed the whole-genome sequence of the strain and designated it BLM-A21. Additional M. tuberculosis  genomes were selected from the Virulence Factor Database (http:\/\/www.mgc.ac.cn\/cgi-bin\/VFs\/genus.cgi?Genus=Mycobacterium ) for comparison. An evolutionary tree of the BLM-A21 strain was built using PhyML maximum likelihood software. Further gene analysis revealed that, except for the pks1  gene, BLM-A21 had similar virulence genes to the CDC 1551 and H37Rv strains, which have lower dissemination.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>We speculate that the pks1  virulence gene in BLM-A21 may be the key virulence gene responsible for the widespread dissemination of M. tuberculosis  infection in this previously healthy adult with normal immune function.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i35.6826","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:54:33Z","timestamp":1729601673000},"page":"6826-6833","source":"Crossref","is-referenced-by-count":0,"title":["<i>psk1<\/i> virulence gene-induced pulmonary and systemic tuberculosis in a young woman with normal immune function: A case report"],"prefix":"10.12998","volume":"12","author":[{"given":"Fan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Lan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Yu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1001-0939.2013.12.003"},{"key":"B2","unstructured":"World Health Organization.   Global tuberculosis report 2017. Geneva: World Health Organization; 2017. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241565516"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1080"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-251-9_6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks465"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2019.04.006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-421"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx081"},{"key":"B9","unstructured":"Zhu BD, Wang HH. [History and current status of tuberculosis vaccine research]. Zhonghua Jiehe He Huxi Zazhi 2007; 30: 378-382"},{"key":"B10","unstructured":"Yang M, Yuan P, Wang Y, Chen L, Shi ZY, Luo DX, Huang XQ. [Analysis of clinical prevalence of 502 cases of hematogenous disseminated pulmonary tuberculosis in Sichuan]. Sichuan Yixue 2018; 39: 977-982"},{"key":"B11","unstructured":"Liu TL.   [Practical tuberculosis]. Shenyang: Liaoning Science and Technology Press; 1987; 284-289"},{"key":"B12","unstructured":"Yun J, Wang AM. [Clinical characteristics of 146 patients with hematogenous disseminated pulmonary tuberculosis and analysis of influencing factors of curative effect]. Zhongguo Bingan 2016; 17: 70-73"},{"key":"B13","unstructured":"Liu XN, Li Y. [Analysis of clinical characteristics and risk factors of young patients with severe pulmonary tuberculosis]. Linchuang Feike Zazhi 2020; 25: 1419-1423"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163318"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05191-4"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1086\/430614"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229700"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i35\/6826.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i35\/6826.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:55:13Z","timestamp":1729601713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i35\/6826.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":17,"journal-issue":{"issue":"35"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i35.6826","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,16]]}}}