{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:53:44Z","timestamp":1785423224530,"version":"3.56.0"},"reference-count":30,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Remimazolam is a new benzodiazepine used for procedural sedation and general anesthesia. Several studies have used remimazolam for bendable bronchoscopy.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To assess the safety and efficacy of remimazolam for sedation in patients undergoing bendable bronchoscopy by performing a meta-analysis of randomized controlled trials (RCTs).<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>We searched the EMBASE, PubMed, Cochrane Library, and Web of Science databases for RCTs on bendable bronchoscopic procedural sedation with remimazolam vs  conventional sedatives (CS).<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>Five studies with 1080 cases were included. Remimazolam had the same sedation success rate compared with CS [relative risk (RR): 1.35, 95%CI: 0.60-3.05, P  = 0.474, I 2 = 99.6%]. However, remimazolam was associated with a lower incidence of hypotension (RR: 0.61; 95%CI: 0.40-0.95, P  = 0.027; I 2 = 65.1%) and a lower incidence of respiratory depression (RR: 0.50, 95%CI: 0.33-0.77, P  = 0.002, I 2 = 42.3%). A subgroup analysis showed a higher success rate of sedation with remimazolam than midazolam (RR: 2.45, 95%CI: 1.76-3.42, P  &lt; 0.001). Compared with propofol, the incidence of hypotension (RR: 0.45, 95%CI: 0.32-0.64, P  &lt; 0.001, I 2 = 0.0%), respiratory depression (RR: 0.48, 95%CI: 0.30-0.76, P  = 0.002, I 2 = 78.4%), hypoxemia (RR: 0.36, 95%CI: 0.15-0.87, P  = 0.023), and injection pain (RR: 0.04, 95%CI: 0.01-0.28, P  = 0.001) were lower.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Remimazolam is safe and effective during bronchoscopy. The sedation success rate was similar to that in the CS group. However, remimazolam has a higher safety profile, with fewer inhibitory effects on respiration and circulation.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i6.1120","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:36:57Z","timestamp":1708407417000},"page":"1120-1129","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of remimazolam in bronchoscopic sedation: A meta-analysis"],"prefix":"10.12998","volume":"12","author":[{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201907-1292SO"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05896-4"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-3361"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001459"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-01880-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0419-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.09.004"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S384155"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000638"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3604-1"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00456"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-022-01487-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202307_32961"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1005367"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.09.015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.902065"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.690875"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110955"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01544-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2196198"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1806"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.04.2351"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000784"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00006412"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.655042"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.22.16631-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.06.027"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.22.16817-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.09.015"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1120.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1120.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:37:58Z","timestamp":1708407478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1120.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":30,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i6.1120","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,26]]}}}