{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:38:10Z","timestamp":1768253890390,"version":"3.49.0"},"reference-count":17,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Retroperitoneal high-grade serous carcinoma (HGSC) of unknown origin is a sporadic tumor that can originate from ovarian cancer. Herein, we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and treated.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U\/mL upon a regular health examination. Computed tomography revealed retroperitoneal lymph node enlargement. Subsequently, positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the nodes. As a result, she underwent laparoscopic lymph node resection, and pathology revealed metastatic adenocarcinoma with CK7(+), PAX8(+), WT1(+), PR(-), and p53 mutational loss of expression, indicating that the origin may be from the adnexa. The patient was admitted to our ward and underwent laparoscopic staging; however, the pathological results were negative. Under the suspicion of retroperitoneal HGSC of unknown origin, chemotherapy and targeted therapy were initiated. Tumor marker levels decreased after treatment.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy, staging surgery, chemotherapy, and targeted therapy.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i6.1190","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:36:57Z","timestamp":1708407417000},"page":"1190-1195","source":"Crossref","is-referenced-by-count":3,"title":["Management of retroperitoneal high-grade serous carcinoma of unknown origin: A case report"],"prefix":"10.12998","volume":"12","author":[{"given":"Wen-Lin","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dah-Ching","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184614"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.61"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094409"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/path.5308"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.07.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2016.08.40"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3975-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210117"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-017-0394-z"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5934-4"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004692"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0484-6"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13878"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.06.075"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01103"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170283"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-017-0296-8"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1190.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1190.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:38:38Z","timestamp":1708407518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i6\/1190.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":17,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i6.1190","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,26]]}}}