{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:32:10Z","timestamp":1792067530054,"version":"4.4.0"},"reference-count":24,"publisher":"Baishideng Publishing Group Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Secondary hemophagocytic lymphohistiocytosis (sHLH) triggered by Salmonella enterica  serovar Typhimurium is rare in pediatric patients. There is no consensus on how to treat S. typhimurium -triggered sHLH.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 9-year-old boy with intermittent fever for 3 d presented to our hospital with positive results for S. typhimurium , human rhinovirus, and Mycoplasma pneumoniae  infections. At the time of admission to our institution, the patient\u2019s T helper 1\/T helper 2 cytokine levels were 326 pg\/mL for interleukin 6 (IL-6), 9.1 pg\/mL for IL-10, and 246.7 pg\/mL for interferon-gamma (IFN-\u03b3), for which the ratio of IL-10 to IFN-\u03b3 was 0.04. In this study, the patient received meropenem, linezolid, and cefoperazone\/sulbactam in combination with high-dose methylprednisolone therapy (10 mg\/kg\/d for 3 d) and antishock supportive treatment twice. After careful evaluation, this patient did not receive HLH chemotherapy and recovered well.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>S.  Typhimurium infection-triggered sHLH patient had a ratio of IL-10 to IFN-\u03b3 \u2264 1.33, an IL-10 concentration \u2264 10.0 pg\/mL, and\/or an IFN-\u03b3 concentration \u2264 225 pg\/mL at admission. Early antimicrobial and supportive treatment was sufficient, and the HLH-94\/2004 protocol was not necessary under these conditions.<\/jats:p>","DOI":"10.12998\/wjcc.v12.i9.1660","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T04:19:08Z","timestamp":1711340348000},"page":"1660-1668","source":"Crossref","is-referenced-by-count":1,"title":["Low interleukin-10 level indicates a good prognosis in <i>Salmonella enterica<\/i> serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis: A case report"],"prefix":"10.12998","volume":"12","author":[{"given":"Yuan-Yuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Zhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15516"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15590"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac649"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2021-139999"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001400"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.624759"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00561-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009441"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14695"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042921-112837"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.11.046"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.850443"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.03.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/10781552211020821"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1159\/000528349"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01973-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-022-03585-3"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6236270"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.5152\/TurkPediatriArs.2016.3956"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s0736-4679(03)00212-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2472"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0385"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_224_20"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i9\/1660.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i9\/1660.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T04:19:52Z","timestamp":1711340392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v12\/i9\/1660.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":24,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.12998\/wjcc.v12.i9.1660","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,26]]}}}