{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T05:20:48Z","timestamp":1732339248928,"version":"3.28.0"},"reference-count":4,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>This manuscript describes the first known cases of sick sinus syndrome (SSS) associated with the use of anlotinib in non-small cell lung cancer patients, highlighting the need for increased vigilance and cardiac monitoring.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment, respectively, presenting with syncope and palpitations. Electrocardiogram confirmed SSS, and different treatment approaches were taken for each patient. One patient received a dual-chamber permanent pacemaker, while the other discontinued the medication and experienced symptom resolution.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Anlotinib can induce SSS, suggesting that cardiac monitoring is crucial during anlotinib treatment. Individualized management strategies are necessary for affected individuals.<\/jats:p>","DOI":"10.12998\/wjcc.v13.i6.98084","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T08:31:00Z","timestamp":1732264260000},"source":"Crossref","is-referenced-by-count":0,"title":["Anlotinib-induced sick sinus syndrome: Two case reports"],"prefix":"10.12998","volume":"13","author":[{"given":"Cheng-Feng","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Fen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30038"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0664-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3771"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S246000"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v13\/i6\/98084.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v13\/i6\/98084.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T08:31:13Z","timestamp":1732264273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v13\/i6\/98084.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":4,"journal-issue":{"issue":"6"},"alternative-id":["98084"],"URL":"https:\/\/doi.org\/10.12998\/wjcc.v13.i6.98084","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,26]]}}}