{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T01:34:05Z","timestamp":1770946445446,"version":"3.50.1"},"reference-count":12,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Cases"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Acute submacular hemorrhage (SMH) secondary to choroidal neovascularization (CNV), most commonly in neovascular age-related macular degeneration, is a vision-threatening emergency. Thick, fovea-involving SMH can cause rapid photoreceptor injury, and timely intervention aimed at clot lysis and displacement, while continuing CNV suppression with anti-vascular endothelial growth factor (anti-VEGF) therapy, may improve anatomic outcomes.<\/jats:p>\n                  <jats:p>CASE SUMMARY<\/jats:p>\n                  <jats:p>We report a retrospective case series of three eyes with acute, fovea-involving CNV-related SMH treated with pars plana vitrectomy (PPV), subretinal tissue plasminogen activator (tPA), and expansile gas tamponade, with intravitreal anti-VEGF administered at the end of the procedure and continued postoperatively. Two cases had early intraocular pressure-related events (transient hypotony in one patient and transient ocular hypertension in another) requiring close postoperative monitoring and medical management. Follow-up color fundus photography and optical coherence tomography documented postoperative evolution of the hemorrhage compared with baseline, with ongoing anti-VEGF therapy planned to control the underlying CNV.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>PPV with subretinal tPA and gas tamponade is a practical surgical strategy for acute, thick, fovea-involving SMH secondary to CNV, particularly when rapid displacement is desired. Careful documentation of operative parameters, strict postoperative monitoring for pressure-related complications, and continued anti-VEGF therapy are essential components of care.<\/jats:p>","DOI":"10.12998\/wjcc.v14.i6.118545","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:59:02Z","timestamp":1770944342000},"source":"Crossref","is-referenced-by-count":0,"title":["Surgical management of acute choroidal neovascularization related submacular hemorrhage: Three case reports"],"prefix":"10.12998","volume":"14","author":[{"given":"Georges","family":"El Mollayess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Jaroudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehya","family":"Tlaiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan","family":"Itaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachir","family":"Abiad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2024.07.024"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.07.023"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88128-8"},{"key":"B4","unstructured":"Handwerger BA, Blodi BA, Chandra SR, Olsen TW, Stevens TS. Treatment of submacular hemorrhage with low-dose intravitreal tissue plasminogen activator injection and pneumatic displacement. Arch Ophthalmol 2001; 28-32"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(00)00734-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004337"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.4297"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-024-03468-9"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0349-8"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3160963"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.04.014"}],"container-title":["World Journal of Clinical Cases"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v14\/i6\/118545.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v14\/i6\/118545.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:59:12Z","timestamp":1770944352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2307-8960\/full\/v14\/i6\/118545.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":12,"journal-issue":{"issue":"6"},"alternative-id":["118545"],"URL":"https:\/\/doi.org\/10.12998\/wjcc.v14.i6.118545","relation":{},"ISSN":["2307-8960"],"issn-type":[{"value":"2307-8960","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}