{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:42:47Z","timestamp":1788493367659,"version":"build-2803163510"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"4","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>We have carried out a prospective, randomised study of prophylaxis for heterotopic ossification (HO) comparing indomethacin for 7 and 14 days, acetylsalicylic acid, and fractional (4 \u00d7 3 Gy) or single exposure of 5 or 7 Gy irradiation after operation.<\/jats:p>\n                  <jats:p>We initially had 723 patients (733 hip replacements), but after withdrawals there were 685 hips of which 18.4% developed HO; 14% were grade I, 2.9% grade II and 1.5% grade III of the Brooker classification.<\/jats:p>\n                  <jats:p>We compared the results between these groups with those of a matched control series and found that indomethacin, 2 \u00d7 50 mg for 7 and 14 days, and postoperative irradiation of 4 \u00d7 3 Gy or 1 \u00d7 7 Gy, significantly reduced the development of HO compared with the control group. Patients in the acetylsalicylic acid group and those with a single irradiation of 5 Gy after operation developed significantly more ossification than those in the indomethacin and other irradiation groups.<\/jats:p>\n                  <jats:p>We suggest the use of 2 \u00d7 50 mg of indomethacin with mucoprotection for seven days as prophylaxis against HO after total hip replacement for all patients. A single irradiation of 7 Gy is recommended for patients who have developed HO after previous operations or to whom administration of indomethacin is contraindicated.<\/jats:p>","DOI":"10.1302\/0301-620x.79b4.0790596","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T06:53:07Z","timestamp":1519195987000},"page":"596-602","source":"Crossref","is-referenced-by-count":327,"title":["PREVENTION OF HETEROTOPIC OSSIFICATION AFTER TOTAL HIP REPLACEMENT"],"prefix":"10.1302","volume":"79-B","author":[{"given":"D.","family":"Knelles","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Julius-Maximilians-University of W\u00fcrzburg, K\u00f6nig-Ludwig Haus, Brettreichstrasse 11\u201313, D-97074 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Barthel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Julius-Maximilians-University of W\u00fcrzburg, K\u00f6nig-Ludwig Haus, Brettreichstrasse 11\u201313, D-97074 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Karrer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Julius-Maximilians-University of W\u00fcrzburg, K\u00f6nig-Ludwig Haus, Brettreichstrasse 11\u201313, D-97074 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Julius-Maximilians-University of W\u00fcrzburg, K\u00f6nig-Ludwig Haus, Brettreichstrasse 11\u201313, D-97074 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Eulert","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Julius-Maximilians-University of W\u00fcrzburg, K\u00f6nig-Ludwig Haus, Brettreichstrasse 11\u201313, D-97074 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"K\u00f6lbl","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Julius-Maximilians-University of W\u00fcrzburg, Josef-Schneider-Strasse, D-97080 W\u00fcrzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.79B4.0790596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.79B4.0790596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T15:06:30Z","timestamp":1629126390000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.79B4.0790596"}},"subtitle":["A PROSPECTIVE, RANDOMISED STUDY USING ACETYLSALICYLIC ACID, INDOMETHACIN AND FRACTIONAL OR SINGLE-DOSE IRRADIATION"],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":0,"aliases":["10.1302\/0301-620x.79b4.6829","10.1302\/0301-620x.79b4.6829","10.1302\/0301-620x.79b4.6829"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1302\/0301-620X.79B4.0790596"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.79b4.0790596","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}