{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:14:28Z","timestamp":1793445268302,"version":"4.5.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p> Haemophilic arthropathy is characterised by iron deposits in synovial tissues. We investigated the suggestion that iron plays an important role in synovial changes. <\/jats:p><jats:p> We obtained synovial tissue from six patients with haemophilia during arthroplasty, finding that brown haemosideritic tissue was often adjacent to tissue with a macroscopically normal appearance in the same joint. Samples from both types of synovial tissue were analysed histologically and biochemically to determine catabolic activity. Macroscopically haemosideritic synovium showed a significantly higher inflammatory activity than that with a normal appearance. Cultures of abnormal synovial tissue gave a significantly enhanced production of IL-1, IL-6 and TNF\u03b1 compared with cultures of synovial tissue with a normal appearance. In addition, the supernatant fluids from the cultures showed greater catabolic activity from haemosideritic tissue, as determined by the inhibition of the synthesis of articular cartilage matrix. <\/jats:p><jats:p> We conclude that in patients with haemophilic arthropathy, local synovial iron deposits are associated with increased catabolic activity. <\/jats:p>","DOI":"10.1302\/0301-620x.80b3.0800540","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:51:58Z","timestamp":1519213918000},"page":"540-545","source":"Crossref","is-referenced-by-count":270,"title":["Iron deposits and catabolic properties of synovial tissue from patients with haemophilia"],"prefix":"10.1302","volume":"80-B","author":[{"given":"G.","family":"Roosendaal","sequence":"first","affiliation":[{"name":"Van Creveld Clinic, National Haemophilia Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Vianen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. G.","family":"Wenting","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"van Rinsum","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Van Creveld Clinic, National Haemophilia Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. P. J. G.","family":"Lafeber","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W. J.","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B3.0800540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B3.0800540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:26:31Z","timestamp":1629141991000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.80B3.0800540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":0,"aliases":["10.1302\/0301-620x.80b3.7807","10.1302\/0301-620x.80b3.7807"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1302\/0301-620X.80B3.0800540"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.80b3.0800540","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}