{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:38:05Z","timestamp":1788543485409,"version":"build-2803163510"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p> In many countries Haemophilus influenzae type b (Hib) is the second most common cause of septic arthritis in children. In Finland large-scale immunisation against Hib using conjugate vaccines began in 1986, four years after a multicentre prospective study of orthopaedic infections in children had started. <\/jats:p><jats:p> Since 1982, including six years before and ten after starting routine Hib vaccination, there has been a major change in the pattern of septic arthritis. From 1982 to 1988, 32 of 61 cases (53%) were caused by staphylococci, 22 (36%) by Hib and 7 (11%) by other bacteria. Since 1988, Hib infection has disappeared, and one-third of cases of childhood septic arthritis has been eliminated. This change has allowed us to reduce initial antimicrobial therapy for such children to cover only Gram-positive cocci. The more limited treatment is safer, reduces cost, and simplifies treatment. <\/jats:p>","DOI":"10.1302\/0301-620x.80b3.0800471","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:51:58Z","timestamp":1519213918000},"page":"471-473","source":"Crossref","is-referenced-by-count":75,"title":["Reduced incidence of septic arthritis in children by <i>Haemophilus influenzae<\/i> type-b vaccination"],"prefix":"10.1302","volume":"80-B","author":[{"given":"H.","family":"Peltola","sequence":"first","affiliation":[{"name":"Helsinki University Central Hospital, Hospital for Children and Adolescents, 11 Stenb\u00e4ck Street, FIN-00290 Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. T.","family":"Kallio","sequence":"additional","affiliation":[{"name":"Helsinki University Central Hospital, Hospital for Children and Adolescents, 11 Stenb\u00e4ck Street, FIN-00290 Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Unkila-Kallio","sequence":"additional","affiliation":[{"name":"Departments I and II of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B3.0800471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B3.0800471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:26:15Z","timestamp":1629141975000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.80B3.0800471"}},"subtitle":["IMPLICATIONS FOR TREATMENT"],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":0,"aliases":["10.1302\/0301-620x.80b3.8296","10.1302\/0301-620x.80b3.8296"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1302\/0301-620X.80B3.0800471"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.80b3.0800471","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}