{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:51:12Z","timestamp":1792061472897,"version":"4.4.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"5","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p> In a series of 12 patients with inoperable gastric carcinoma who had treatment with a synthetic matrix metalloproteinase inhibitor (Marimastat) for more than one month, six developed a frozen shoulder or a condition resembling Dupuytren\u2019s disease. <\/jats:p><jats:p> This suggests that the matrix metalloproteinases, a family of naturally occurring proteinases, may be involved in the pathogenesis of these two conditions. Our observation opens avenues for further research which could lead to local or systemic therapeutic interventions for frozen shoulder and Dupuytren\u2019s disease. <\/jats:p>","DOI":"10.1302\/0301-620x.80b5.0800907","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:51:41Z","timestamp":1519213901000},"page":"907-908","source":"Crossref","is-referenced-by-count":366,"title":["Dupuytren\u2019s disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor"],"prefix":"10.1302","volume":"80-B","author":[{"given":"J. W.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"University Hospital, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Tierney","sequence":"additional","affiliation":[{"name":"University Hospital, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Parsons","sequence":"additional","affiliation":[{"name":"University Hospital, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. R. C.","family":"Davis","sequence":"additional","affiliation":[{"name":"University Hospital, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B5.0800907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.80B5.0800907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:25:18Z","timestamp":1629141918000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.80B5.0800907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":0,"aliases":["10.1302\/0301-620x.80b5.8464","10.1302\/0301-620x.80b5.8464","10.1302\/0301-620x.80b5.8464"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1302\/0301-620X.80B5.0800907"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.80b5.0800907","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}