{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:06:50Z","timestamp":1792400810591,"version":"4.4.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"4","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p> Heritable thrombophilic disorders have been proposed as one of the causes for Legg-Calv\u00e9-Perthes disease. A total of 62 patients diagnosed with this disease between 1988 and 1997 and 50 controls were screened for thrombophilia. The incidence and relationship of thrombophilia to the severity of the disease were evaluated. <\/jats:p><jats:p> One patient and none of the controls had protein S deficiency. One of the control group and one of the patients had protein C deficiency with the latter child also having a combined deficiency with a mutant factor V gene. <\/jats:p><jats:p> The number of children with a mutant factor V gene, protein C deficiency, who were homozygous for the C 677T polymorphism of methylenetetra-hydrofolate reductase or were heterozygous for mutant G20210A prothrombin did not differ statistically in the study and the control groups. No patient had antithrombin deficiency or positive lupus anticoagulant. <\/jats:p><jats:p> We found no correlation between thrombophilia and the extent of the disease. The most common risk factors for arteriovenous thromboembolism showed no statistical significance in our patients compared with the control group or with the general population. These data do not confirm an aetiological role for thrombophilia in Perthes\u2019 disease. <\/jats:p>","DOI":"10.1302\/0301-620x.81b4.0810686","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:51:05Z","timestamp":1519213865000},"page":"686-690","source":"Crossref","is-referenced-by-count":81,"title":["Does thrombophilia play an aetiological role in Legg-Calv\u00e9-Perthes disease?"],"prefix":"10.1302","volume":"81-B","author":[{"given":"S.","family":"Hayek","sequence":"first","affiliation":[{"name":"Department of Paediatric Orthopedics, Dana Children\u2019s Hospital, 6 Weizman Street, Tel-Aviv 64239, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kenet","sequence":"additional","affiliation":[{"name":"The National Hemophilia Centre and Institute of Thrombosis and Haemostasis, Sheba Medical Centre, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lubetsky","sequence":"additional","affiliation":[{"name":"The National Hemophilia Centre and Institute of Thrombosis and Haemostasis, Sheba Medical Centre, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"The National Hemophilia Centre and Institute of Thrombosis and Haemostasis, Sheba Medical Centre, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gitel","sequence":"additional","affiliation":[{"name":"The National Hemophilia Centre and Institute of Thrombosis and Haemostasis, Sheba Medical Centre, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wientroub","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopedics, Dana Children\u2019s Hospital, 6 Weizman Street, Tel-Aviv 64239, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.81B4.0810686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.81B4.0810686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:22:24Z","timestamp":1629141744000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.81B4.0810686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":0,"aliases":["10.1302\/0301-620x.81b4.9378","10.1302\/0301-620x.81b4.9378"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1302\/0301-620X.81B4.0810686"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.81b4.0810686","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}