{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:06:50Z","timestamp":1792400810593,"version":"4.4.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"5","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p> Recent reports have suggested an association between Perthes\u2019 disease and an underlying thrombophilic or hypofibrinolytic tendency. In Northern Ireland there is a high incidence of Perthes\u2019 disease (11.7 per 100 000 or 1 in 607 children) in a stable paediatric population. <\/jats:p><jats:p> We reviewed 139 children with Perthes\u2019 disease and compared them with a control group of 220 aged- and gender-matched healthy primary schoolchildren with similar racial and ethnic backgrounds. <\/jats:p><jats:p> There were no significant deficiencies of antithrombotic factors protein C, protein S, antithrombin III or resistance to activated protein C. A total of 53 (38.1%) of the children with Perthes\u2019 disease had a prolonged activated partial thromboplastin time (&gt; 38) compared with 13 (5.9%) of the control group (p &lt; 0.001). Our findings have shown that using standard assays, thrombophilia secondary to antithrombotic factor deficiency or resistance to activated protein does not appear to be an aetiological factor for Perthes\u2019 disease. The cause of the prolonged activated partial thromboplastin time, usually associated with a clotting factor deficiency, is under further investigation. <\/jats:p>","DOI":"10.1302\/0301-620x.82b5.0820744","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T11:49:34Z","timestamp":1519213774000},"page":"744-746","source":"Crossref","is-referenced-by-count":36,"title":["The role of coagulation abnormalities in the development of Perthes\u2019 disease"],"prefix":"10.1302","volume":"82-B","author":[{"given":"W. D. C.","family":"Kealey","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Musgrave Park Hospital, Stockmans Lane, Belfast BT9 7JB, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. E.","family":"Mayne","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Musgrave Park Hospital, Stockmans Lane, Belfast BT9 7JB, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.82B5.0820744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.82B5.0820744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T19:20:13Z","timestamp":1629141613000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.82B5.0820744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":0,"aliases":["10.1302\/0301-620x.82b5.10183"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1302\/0301-620X.82B5.0820744"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.82b5.0820744","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}