{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:12:44Z","timestamp":1792271564226,"version":"4.4.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p> Dupuytren\u2019s disease is a benign fibroproliferative disease of unknown aetiology. It is often familial and commonly affects Northern European Caucasian men, but genetic studies have yet to identify the relevant genes. <\/jats:p><jats:p> Transforming growth factor beta one (TGF-\u03b21) is a multifunctional cytokine which plays a central role in wound healing and fibrosis. It stimulates the proliferation of fibroblasts and the deposition of extracellular matrix. Previous studies have implicated TGF-\u03b21 in Dupuytren\u2019s disease, suggesting that it may represent a candidate susceptibility gene for this condition. <\/jats:p><jats:p> We have investigated the association of four common single nucleotide polymorphisms in TGF-\u03b21 with the risk of developing Dupuytren\u2019s disease. A polymerase chain reaction-restriction fragment length polymorphism method was used for genotyping TGF-\u03b21 polymorphisms. DNA samples from 135 patients with Dupuytren\u2019s disease and 200 control subjects were examined. <\/jats:p><jats:p> There was no statistically significant difference in TGF-\u03b21 genotype or allele frequency distributions between the patients and controls for the codons 10, 25, \u2212509 and \u2212800 polymorphisms. <\/jats:p><jats:p> Our observations suggest that common TGF-\u03b21 polymorphisms are not associated with a risk of developing Dupuytren\u2019s disease. These data should be interpreted with caution since the lack of association was shown in only one series of patients with only known, common polymorphisms of TGF-\u03b21. To our knowledge, this is the first report of a case-control association study in Dupuytren\u2019s disease using single nucleotide polymorphisms in TGF-\u03b21. <\/jats:p>","DOI":"10.1302\/0301-620x.84b2.0840211","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:23:20Z","timestamp":1519241000000},"page":"211-215","source":"Crossref","is-referenced-by-count":38,"title":["Genetic susceptibility in Dupuytren\u2019s disease"],"prefix":"10.1302","volume":"84-B","author":[{"given":"A.","family":"Bayat","sequence":"first","affiliation":[{"name":"Centre for Integrated Genomic Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Withington Hospital, Nell Lane, West Didsbury, Manchester M20 2LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Wrightington Hospital, Hall Lane, Wigan, Lancashire WN6 9EP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alansari","sequence":"additional","affiliation":[{"name":"Centre for Integrated Genomic Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Withington Hospital, Nell Lane, West Didsbury, Manchester M20 2LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W. J.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. E. R.","family":"Ollier","sequence":"additional","affiliation":[{"name":"Centre for Integrated Genomic Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B2.0840211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B2.0840211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:17:17Z","timestamp":1629145037000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.84B2.0840211"}},"subtitle":["TGF-\u03b21 POLYMORPHISMS AND DUPUYTREN\u2019S DISEASE"],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":0,"aliases":["10.1302\/0301-620x.84b2.12083"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1302\/0301-620X.84B2.0840211"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.84b2.0840211","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}