{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:05:17Z","timestamp":1791054317849,"version":"4.1.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>Herniated intervertebral disc tissue has been shown to produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain.<\/jats:p>\n                  <jats:p>\n                    We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) in disc tissue from patients undergoing discectomy for sciatica (63) with that from patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay.\n                  <\/jats:p>\n                  <jats:p>There was a statistically significant difference between levels of production of IL-6 and IL-8 in the sciatica and low back pain groups (p &lt; 0.006 and p &lt; 0.003, respectively).<\/jats:p>\n                  <jats:p>The high levels of proinflammatory mediator found in disc tissue from patients undergoing fusion suggest that production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of a painful lumbar disc.<\/jats:p>","DOI":"10.1302\/0301-620x.84b2.0840196","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T14:23:20Z","timestamp":1519223000000},"page":"196-201","source":"Crossref","is-referenced-by-count":1322,"title":["Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators"],"prefix":"10.1302","volume":"84-B","author":[{"given":"J. G.","family":"Burke","sequence":"first","affiliation":[{"name":"Mater Misericordiae Hospital, 47 Eccles Street, Dublin 7, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. G.","family":"Watson","sequence":"additional","affiliation":[{"name":"Mater Misericordiae Hospital, 47 Eccles Street, Dublin 7, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"McCormack","sequence":"additional","affiliation":[{"name":"Mater Misericordiae Hospital, 47 Eccles Street, Dublin 7, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. E.","family":"Dowling","sequence":"additional","affiliation":[{"name":"Meath\/Adelaide\/National Children\u2019s Hospital, Tallaght, Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Mater Misericordiae Hospital, 47 Eccles Street, Dublin 7, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Mater Misericordiae Hospital, 47 Eccles Street, Dublin 7, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B2.0840196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B2.0840196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T16:17:14Z","timestamp":1629130634000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.84B2.0840196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":0,"aliases":["10.1302\/0301-620x.84b2.12511","10.1302\/0301-620x.84b2.11937","10.1302\/0301-620x.84b2.12511","10.1302\/0301-620x.84b2.12511"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1302\/0301-620X.84B2.0840196"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.84b2.0840196","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}