{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:46:43Z","timestamp":1791931603916,"version":"4.3.4"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p> From the European Osteosarcoma Intergroup study 202 patients were assessed with respect to their surgical treatment. Although treated in three different centres the survival of the three groups was identical (57% at five years). Two of the centres had rates of limb salvage of 85% and 83%, respectively, while the third had a rate of 49%. The corresponding risks of local recurrence were 13.3%, 6.8% and 2.5%, with all local recurrences arising in limbs with attempted limb salvage. Local recurrence was closely related to the adequacy of the margins of excision and to the chemotherapeutic response. Patients who had undergone limb-salvage surgery and who developed local recurrence still survival at five years). Of patients who relapsed, 31% of those with local recurrence alone were cured by further treatment, as compared with only 10% of those with metastases. Limb-salvage surgery with effective chemotherapy remains the optimum treatment for osteosarcoma. <\/jats:p>","DOI":"10.1302\/0301-620x.84b3.0840395","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:21:58Z","timestamp":1519240918000},"page":"395-400","source":"Crossref","is-referenced-by-count":278,"title":["Surgical outcomes in osteosarcoma"],"prefix":"10.1302","volume":"84-B","author":[{"given":"R. J.","family":"Grimer","sequence":"first","affiliation":[{"name":"Oncology Service, Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Taminiau","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, PB 2600, 2300Rc Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B3.0840395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.84B3.0840395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:16:14Z","timestamp":1629144974000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.84B3.0840395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":0,"aliases":["10.1302\/0301-620x.84b3.12019","10.1302\/0301-620x.84b3.12019"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1302\/0301-620X.84B3.0840395"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.84b3.0840395","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}