{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:23:51Z","timestamp":1790400231948,"version":"4.1.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p> Our aims were to describe the distribution of \u03b1-smooth muscle actin (SMA)-containing cells in Dupuytren\u2019s tissue in vivo and to determine the effects of selected agents in regulating the expression of SMA in Dupuytren\u2019s cells in vitro. <\/jats:p><jats:p> In selected hypercellular zones of Dupuytren\u2019s nodules up to 40% of the cells contained SMA, as shown by immunohistochemistry. A lower percentage (20%) of SMA-containing cells was found in regions of lower cellularity. A notable finding was that treatment in vitro of Dupuytren\u2019s cells with platelet-derived growth factor significantly reduced the content of SMA. Cells from the same patients showed a significant increase in expression of SMA in response to treatment with transforming growth factor, which confirmed recent findings. In addition, interferon-\u03b3, which has been previously used as a treatment for Dupuytren\u2019s disease in a clinical study, had no reproducible effect on the expression of this actin isoform. Our findings are of significance for the conservative management of contractures. <\/jats:p>","DOI":"10.1302\/0301-620x.85b3.13219","type":"journal-article","created":{"date-parts":[[2003,7,15]],"date-time":"2003-07-15T22:32:53Z","timestamp":1058308373000},"page":"448-455","source":"Crossref","is-referenced-by-count":24,"title":["Regulation of expression of \u03b1-smooth muscle actin in cells of Dupuytren\u2019s contracture"],"prefix":"10.1302","volume":"85-B","author":[{"given":"H. B.","family":"Hindman","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Marty-Roix","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-B.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Nantong Medical College, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Jupiter","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.85B3.13219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.85B3.13219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:15:07Z","timestamp":1629144907000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.85B3.13219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1302\/0301-620X.85B3.13219"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.85b3.13219","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}