{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:06:44Z","timestamp":1792400804511,"version":"4.4.0"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p> It has recently been postulated that thrombophilia may have a role in the aetiology of Perthes\u2019 disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes\u2019 disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisingly four of them had a homozygous pattern. These four patients showed the most severe form of the disease, Catterall group IV, with flattening of the entire epiphysis, involvement of the metaphysis, shortening and broadening of the femoral neck, trochanteric overgrowth and developed mushroom-shaped aspherical laterally displaced femoral heads in dysplastic acetabula. <\/jats:p><jats:p> We would like to suggest that the homozygous form of Factor V Leiden mutation has some role in the clinical course of Perthes\u2019 disease and particularly its most severe form. <\/jats:p>","DOI":"10.1302\/0301-620x.86b3.13442","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T23:25:06Z","timestamp":1081293906000},"page":"426-429","source":"Crossref","is-referenced-by-count":28,"title":["The most severe forms of Perthes\u2019 disease associated with the homozygous Factor V Leiden mutation"],"prefix":"10.1302","volume":"86-B","author":[{"given":"K.","family":"Szepesi","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"P\u00f2s\u00e1n","sequence":"additional","affiliation":[{"name":"Second Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"H\u00e1rsfalvi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen, Medical and Health Science Center, H-4012 Debrecen, Nagyerdei str. 98, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9","family":"Ajzner","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen, Medical and Health Science Center, H-4012 Debrecen, Nagyerdei str. 98, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sz\u00fccs","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"G\u00e1sp\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Csern\u00e1tony","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Udvardy","sequence":"additional","affiliation":[{"name":"Second Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.86B3.13442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.86B3.13442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:10:15Z","timestamp":1629144615000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.86B3.13442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1302\/0301-620X.86B3.13442"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.86b3.13442","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}