{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:40:38Z","timestamp":1775634038593,"version":"3.50.1"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p> We investigated the effect of calcitonin in the prevention of acute bone loss after a pertrochanteric fracture and its ability to reduce the incidence of further fractures in the same patient. <\/jats:p><jats:p> Fifty women aged between 70 and 80 years who had a pertrochanteric fracture of the hip were randomly allocated to group A (200 IU of nasal salmon calcitonin daily for three months) or group B (placebo). <\/jats:p><jats:p> Patients in group A showed a significantly higher level of total alkaline phosphatase and osteocalcin on the 15th day after injury and a significantly higher level of bone alkaline phosphatase on the 90th day after surgery. These patients also had significantly lower levels of urinary C-telopeptide (CrossLaps) on the 15th, 45th and 90th days after injury and lower levels of urinary hydroxyproline on the 15th and 45th days after injury. Patients in group A had significantly higher bone mineral density at all recorded sites except the greater trochanter at three months and one year after operation. After a four-year period of clinical observation, five patients (24%) in group B sustained a new fracture, in four of whom (20%) it was of the contralateral hip. <\/jats:p><jats:p> Our findings show that calcitonin reduces acute bone loss in patients with pertrochanteric fractures and may prevent the occurrence of new fractures of the contralateral hip in the elderly. <\/jats:p>","DOI":"10.1302\/0301-620x.86b3.14300","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T23:25:06Z","timestamp":1081293906000},"page":"350-358","source":"Crossref","is-referenced-by-count":22,"title":["The effects of calcitonin on acute bone loss after pertrochanteric fractures"],"prefix":"10.1302","volume":"86-B","author":[{"given":"T.","family":"Karachalios","sequence":"first","affiliation":[{"name":"Orthopaedic Department, School of Medicine, Faculty of Health Sciences, University of Thessaly, 22 Papakyriazi Street, Larissa 41222, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Lyritis","sequence":"additional","affiliation":[{"name":"Laboratory for the Reseach of the Musculoskeletal System \u201cT. Garofalidis\u201d, KAT Hospital, University of Athens, Kifisia 14561, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaloudis","sequence":"additional","affiliation":[{"name":"Laboratory for the Reseach of the Musculoskeletal System \u201cT. Garofalidis\u201d, KAT Hospital, University of Athens, Kifisia 14561, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Roidis","sequence":"additional","affiliation":[{"name":"Orthopaedic Department, School of Medicine, Faculty of Health Sciences, University of Thessaly, 22 Papakyriazi Street, Larissa 41222, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Katsiri","sequence":"additional","affiliation":[{"name":"Laboratory for the Reseach of the Musculoskeletal System \u201cT. Garofalidis\u201d, KAT Hospital, University of Athens, Kifisia 14561, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.86B3.14300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.86B3.14300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:10:08Z","timestamp":1629144608000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.86B3.14300"}},"subtitle":["A PROSPECTIVE, RANDOMISED TRIAL"],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1302\/0301-620X.86B3.14300"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.86b3.14300","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}