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However, the underlying biology remains unknown. <\/jats:p><jats:p> We report the first histological observations of vancomycin-supplemented impacted bone allografts in two reconstructions performed 14 and 20 months after revision surgery because of a periprosthetic fracture. <\/jats:p><jats:p> Areas of active bone remodelling (creeping substitution), as well as calcified bone trabeculae and graft particles embedded in dense fibrous tissue, were observed with osteoid and fibroconnective tissue surrounding polymethylmethacrylate particles. <\/jats:p><jats:p> These pathological findings are similar to those reported in allografts without vancomycin and support the hypothesis that high levels of vancomycin do not affect the incorporation of bone graft. <\/jats:p>","DOI":"10.1302\/0301-620x.87b12.16781","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T18:23:49Z","timestamp":1133547829000},"page":"1684-1687","source":"Crossref","is-referenced-by-count":27,"title":["Histology of vancomycin-supplemented impacted bone allografts in revision total hip arthroplasty"],"prefix":"10.1302","volume":"87-B","author":[{"given":"M. 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