{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:10:05Z","timestamp":1790903405970,"version":"4.1.0"},"reference-count":18,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p> Autologous chondrocyte implantation (ACI) is a technique used for the treatment of symptomatic osteochondral defects of the knee. A variation of the original periosteum membrane technique is the matrix-induced autologous chondrocyte implantation (MACI) technique. The MACI membrane consists of a porcine type-I\/III collagen bilayer seeded with chondrocytes. Osteochondral defects deeper than 8 to 10 mm usually require bone grafting either before or at the time of transplantation of cartilage. We have used a variation of Peterson\u2019s ACI-periosteum sandwich technique using two MACI membranes with bone graft which avoids periosteal harvesting. The procedure is suture-free and requires less operating time and surgical exposure. We performed this MACI-sandwich technique on eight patients, five of whom were assessed at six months and one year post-operatively using the modified Cincinnati knee, the Stanmore functional rating and the visual analogue pain scores. <\/jats:p><jats:p> All patients improved within six months with further improvement at one year. The clinical outcome was good or excellent in four after six months and one year. No significant graft-associated complications were observed. Our early results of the MACI-sandwich technique are encouraging although larger medium-term studies are required before there is widespread adoption of the technique. <\/jats:p>","DOI":"10.1302\/0301-620x.87b3.15552","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T22:27:48Z","timestamp":1109111268000},"page":"330-332","source":"Crossref","is-referenced-by-count":167,"title":["Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft"],"prefix":"10.1302","volume":"87-B","author":[{"given":"W.","family":"Bartlett","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. R.","family":"Gooding","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. J.","family":"Carrington","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. R.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B7.13672"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465020300011601"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.36144"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1177\/230949900301100104"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B2.13543"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0160(03)00041-3"},{"key":"R8","unstructured":"Zheng MH, Wood D. The basic science of matrices and cellular repair. In: Bentley G, ed. Current developments in autologous chondrocyte transplantation: round table series 77. London: Royal Society of Medicine Press, 2003;77:49\u201354."},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200201000-00030"},{"key":"R10","unstructured":"Fabian S. Clinical experience with MACI. In: Bentley G, ed. Current developments in autologous chondrocyte transplantation: round table series 77. London: Royal Society of Medicine Press, 2003;77:35\u201340."},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Peterson L, Minas T, Brittberg M, et al. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. 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