{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:10:03Z","timestamp":1790903403667,"version":"4.1.0"},"reference-count":19,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p> We prospectively studied the clinical, arthroscopic and histological results of collagen-covered autologous chondrocyte implantation (ACI-C) in patients with symptomatic osteochondritis dissecans of the knee. The study included 37 patients who were evaluated at a mean follow-up of 4.08 years. <\/jats:p><jats:p> Clinical results showed a mean improvement in the modified Cincinnati score from 46.1 to 68.4. Excellent and good clinical results were seen in 82.1% of those with juvenile-onset osteochondritis dissecans but in only 44.4% of those with adult-onset disease. <\/jats:p><jats:p> Arthroscopy at one year revealed International Cartilage Repair Society grades of 1 or 2 in 21 of 24 patients (87.5%). Of 23 biopsies, 11 (47.8%) showed either a hyaline-like or a mixture of hyaline-like and fibrocartilage, 12 (52.2%) showed fibrocartilage. <\/jats:p><jats:p> The age at the time of ACI-C determined the clinical outcome for juvenile-onset disease (p = 0.05), whereas the size of the defect was the major determinant of outcome in adult-onset disease (p = 0.01). <\/jats:p>","DOI":"10.1302\/0301-620x.88b2.17009","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T18:48:46Z","timestamp":1138128526000},"page":"203-205","source":"Crossref","is-referenced-by-count":83,"title":["Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee"],"prefix":"10.1302","volume":"88-B","author":[{"given":"S. P.","family":"Krishnan","sequence":"first","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. J.","family":"Carrington","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. R.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Schenck RC Jr, Goodnight JM. Osteochondritis dissecans. J Bone Joint Surg [Am] 1996;78-A:439\u201356.","DOI":"10.2106\/00004623-199603000-00018"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Peterson L, Minas T, Brittberg M, Lindahl A. Treatment of osteochondritis disse-cans of the knee with autologous chondrocyte implantation: results at two to ten years. 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