{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:51:19Z","timestamp":1776984679301,"version":"3.51.4"},"reference-count":21,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p> Between 1966 and 2001, 1254 patients underwent excision of a bone tumour with endoprosthetic replacement. All patients who had radiotherapy were identified. Their clinical details were retrieved from their records. <\/jats:p><jats:p> A total of 63 patients (5%) had received adjunctive radiotherapy, 29 pre-operatively and 34 post-operatively. The mean post-operative Musculoskeletal Tumor Society scores of irradiated patients were significantly lower (log-rank test, p = 0.009). The infection rate in the group who had not been irradiated was 9.8% (117 of 1191), compared with 20.7% (6 of 29) in those who had pre-operative radiotherapy and 35.3% (12 of 34) in those who radiotherapy post-operatively. The infection-free survival rate at ten years was 85.5% for patients without radiotherapy, 74.1% for those who had pre-operative radiotherapy and 44.8% for those who had post-operative radiotherapy (log-rank test, p &lt; 0.001). The ten-year limb salvage rate was 89% for those who did not have radiotherapy and 76% for those who did (log-rank test, p = 0.02). <\/jats:p><jats:p> Radiotherapy increased the risk of revision (log-rank test, p = 0.015). A total of ten amputations were necessary to control infection, of which nine were successful. Radiotherapy may be necessary for the treatment of a bone sarcoma but increases the risk of deep infection for which amputation may be the only solution. <\/jats:p>","DOI":"10.1302\/0301-620x.89b10.19233","type":"journal-article","created":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T19:51:55Z","timestamp":1193169115000},"page":"1352-1355","source":"Crossref","is-referenced-by-count":28,"title":["The risks and benefits of radiotherapy with massive endoprosthetic replacement"],"prefix":"10.1302","volume":"89-B","author":[{"given":"L. M.","family":"Jeys","sequence":"first","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Luscombe","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Grimer","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Abudu","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Tillman","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Carter","sequence":"additional","affiliation":[{"name":"Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9483-8"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.62B1.6927980"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Jeys LM, Grimer RJ, Carter SR, Tillman RM. Periprosthetic infection in patients treated for an orthopaedic oncological condition. J Bone Joint Surg [Am] 2005;87-A:842\u20139.","DOI":"10.2106\/JBJS.C.01222"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200202000-00022"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Enneking WF, Durham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of the reconstructive procedures after the surgical treatment of tumors of the musculoskeletal system. Clin Orthop 1993;286:241\u20136.","DOI":"10.1097\/00003086-199301000-00035"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01191-4"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Thompson LH, Suit HD. Proliferation kinetics of X-irradiated mouse L cells studied with time-lapse photography. Int J Radiat Biol 1969;15:347\u201362.","DOI":"10.1080\/09553006914550571"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0283:SARIAO]2.0.CO;2"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1053\/srao.2002.31360"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00095-G"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01524-3"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060191"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6823(1999)7:4<238::AID-ROI5>3.0.CO;2-4"},{"key":"R14","unstructured":"Hopewell JW. The importance of vascular damage in the development of late radiation effects in normal tissues. In: Meyn RE, Withers HR, eds. Radiation biology in cancer research. New York: Raven Press, 1980:449\u201359."},{"key":"R15","unstructured":"Fajardo LF. Morphology of radiation effects on normal tissues. In: Perez CA, Brady LW, eds. Principles and practice of radiation oncology. Second ed. Philadelphia: JB Lippincott Company, 1992:114\u201323."},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Hopewell JW, Young CM. Changes in the microcirculation of normal tissues after irradiation. Int J Radiat Oncol Biol Phys 1978;4:53\u20138.","DOI":"10.1016\/0360-3016(78)90115-3"},{"key":"R17","unstructured":"Withers HR, Peters LJ, Kogelnik HD. The pathobiology of late effects of irradiation. In: Meyn RE, Withers HR, eds. Radiation biology in cancer research. New York: Raven Press, 1980:439\u201348."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20095"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20752"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9188"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09292-9"}],"container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.89B10.19233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.89B10.19233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.89B10.19233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T20:27:21Z","timestamp":1629145641000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.89B10.19233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1302\/0301-620X.89B10.19233"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.89b10.19233","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}