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Our aim was to identify patients at risk for a delayed recovery and particularly those likely to develop complex regional pain syndrome. In order to quantify clinically the inflammatory response, a regional inflammatory score was developed. In addition, blood samples were collected from the antecubital veins of both arms for comparative biochemical and blood-gas analysis. <\/jats:p><jats:p> The severity of the inflammatory response was related to the type of treatment (Kruskal-Wallis test, p = 0.002). A highly significantly-positive correlation was found between the regional inflammatory score and the length of time to full recovery (r<jats:sup>2<\/jats:sup> = 0.92, p = 0.01, linear regession). A regional inflammatory score of 5 points with a sensitivity of 100% but a specificity of only 16% also identified patients at risk of complex regional pain syndrome. None of the biochemical parameters studied correlated with regional inflammatory score or predicted the development of complex regional pain syndrome. <\/jats:p><jats:p> Our study suggests that patients with a distal radial fracture and a regional inflammatory score of 5 points or more at eight to nine weeks after injury should be considered for specific anti-inflammatory treatment. <\/jats:p>","DOI":"10.1302\/0301-620x.89b8.18620","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T23:17:52Z","timestamp":1188947872000},"page":"1069-1076","source":"Crossref","is-referenced-by-count":12,"title":["Delayed recovery and late development of complex regional pain syndrome in patients with an isolated fracture of the distal radius"],"prefix":"10.1302","volume":"89-B","author":[{"given":"R. J. 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