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Osteolytic lesions were classified by their size and location, with cavities &gt; 10 mm in diameter considered to be \u2018marked\u2019. CT scanning was undertaken in all patients with marked osteolysis seen on the plain radiographs. <\/jats:p><jats:p> Osteolytic lesions were seen on the plain films in 48 (37%) and marked lesions in 27 (21%) ankles. The risk for osteolysis was found to be 3.1 (95% confidence interval 1.6 to 5.9) times higher with implants with Ti-HA porous coating. <\/jats:p><jats:p> Care should be taken with ankle arthroplasty until more is known about the reasons for these severe osteolyses. <\/jats:p>","DOI":"10.1302\/0301-620x.91b7.22434","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T21:39:10Z","timestamp":1246397950000},"page":"907-914","source":"Crossref","is-referenced-by-count":111,"title":["Severe periprosthetic osteolytic lesions after the Ankle Evolutive System total ankle replacement"],"prefix":"10.1302","volume":"91-B","author":[{"given":"H.","family":"Koivu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Turku University Hospital, Surgical Hospital, Luolavuorentie 2, 20720 Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kohonen","sequence":"additional","affiliation":[{"name":"The Medical Imaging Centre of Southwest Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sipola","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rheumaorthopaedic Unit, Turku University Hospital, Paimio Hospital, Alvar Aallon tie 275, 21540, Preitila, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Alanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Turku, Lemminkaisenkatu 1, 20014, Turun Yliopisto, Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tiusanen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rheumaorthopaedic Unit, Turku University Hospital, Paimio Hospital, Alvar Aallon tie 275, 21540, Preitila, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Pyevich MT, Saltzman CL, Callaghan JJ, Alvine FG. 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