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We analysed our entire series of 660 metal-on-metal resurfacings (Articular Surface Replacement (ASR) and Birmingham Hip Resurfacing (BHR)) and large-bearing ASR total hip replacements, to establish associations with metal debris-related failures. Clinical and radiological outcomes, metal ion levels, explant studies and lymphocyte transformation tests were performed. A total of 17 patients (3.4%) were identified (all ASR bearings) with adverse reactions to metal debris, for which revision was required. This group had significantly smaller components, significantly higher acetabular component anteversion, and significantly higher whole concentrations of blood and joint chromium and cobalt ions than asymptomatic patients did (all p &lt; 0.001). Post-revision lymphocyte transformation tests on this group showed no reactivity to chromium or cobalt ions. Explants from these revisions had greater surface wear than retrievals for uncomplicated fractures. The absence of adverse reactions to metal debris in patients with well-positioned implants usually implies high component wear.<\/jats:p><jats:p>Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement.<\/jats:p>","DOI":"10.1302\/0301-620x.92b1.22770","type":"journal-article","created":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:22:43Z","timestamp":1262305363000},"page":"38-46","source":"Crossref","is-referenced-by-count":634,"title":["Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement"],"prefix":"10.1302","volume":"92-B","author":[{"given":"D. J.","family":"Langton","sequence":"first","affiliation":[{"name":"Joint Replacement Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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