{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:37:37Z","timestamp":1790617057283,"version":"4.1.0"},"reference-count":22,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p> Short intense electrical pulses transiently increase the permeability of the cell membrane, an effect known as electroporation. This can be combined with antiblastic drugs for ablation of tumours of the skin and subcutaneous tissue. The aim of this study was to test the efficacy of electroporation when applied to bone and to understand whether the presence of mineralised trabeculae would affect the capability of the electric field to porate the membrane of bone cells. <\/jats:p><jats:p> Different levels of electrical field were applied to the femoral bone of rabbits. The field distribution and modelling were simulated by computer. Specimens of bone from treated and control rabbits were obtained for histology, histomorphometry and biomechanical testing. <\/jats:p><jats:p> After seven days, the area of ablation had increased in line with the number of pulses and\/or with the amplitude of the electrical field applied. The osteogenic activity in the ablated area had recovered by 30 days. Biomechanical testing showed structural integrity of the bone at both times. <\/jats:p><jats:p> Electroporation using the appropriate combination of voltage and pulses induced ablation of bone cells without affecting the recovery of osteogenic activity. It can be an effective treatment in bone and when used in combination with drugs, an option for the treatment of metastases. <\/jats:p>","DOI":"10.1302\/0301-620x.92b11.24664","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:08:19Z","timestamp":1288570099000},"page":"1614-1620","source":"Crossref","is-referenced-by-count":49,"title":["Ablation of bone cells by electroporation"],"prefix":"10.1302","volume":"92-B","author":[{"given":"M.","family":"Fini","sequence":"first","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tschon","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ronchetti","sequence":"additional","affiliation":[{"name":"IGEA S.p.A., via Parmenide 10\/A, Carpi, 41012 Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cavani","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, University of Modena and Reggio Emilia, via del Pozzo 71, 41125 Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"5th Ward of Oncologic, Orthopaedic-Trauma Surgery, Rizzoli Orthopaedic Institute, via Pupilli 1, 40100 Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"5th Ward of Oncologic, Orthopaedic-Trauma Surgery, Rizzoli Orthopaedic Institute, via Pupilli 1, 40100 Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alberghini","sequence":"additional","affiliation":[{"name":"Anatomy and Pathological Histology Unit, Rizzoli Orthopaedic Institute, via di Barbiano 1\/10, 40136 Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cadossi","sequence":"additional","affiliation":[{"name":"IGEA S.p.A., via Parmenide 10\/A, Carpi, 41012 Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01867861"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1982.tb01257.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-8981-8"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1177\/153303460700600402"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-4598(00)00112-4"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01093.x"},{"key":"R7","unstructured":"Mir LM, Belehradek M, Domenge C, et al. 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