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The device was applied to 16 rabbits who underwent resection of the articular cartilage and subchondral bone from the entire tibial plateau. In group A (nine rabbits) the device was applied for six months. In group B (seven rabbits) it was in place for six months, after which it was removed and the animals were allowed to move freely for an additional six months. The cartilage remained sound in all rabbits. The areas of type II collagen-positive staining and repaired soft tissue were larger in group B than in group A. These findings provide evidence of long-term persistence of repaired cartilage with this technique and that weight-bearing has a positive effect on the quality of the cartilage.<\/jats:p>","DOI":"10.1302\/0301-620x.92b7.23200","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T23:29:28Z","timestamp":1277940568000},"page":"1033-1040","source":"Crossref","is-referenced-by-count":21,"title":["Joint distraction and movement for repair of articular cartilage in a rabbit model with subsequent weight-bearing"],"prefix":"10.1302","volume":"92-B","author":[{"given":"T.","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery China-Japan Union Hospital of Jilin University, 126 Xian Tai Street, Changchun, Jilin 130033, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1998.0242"},{"key":"R2","unstructured":"van Roermund PM, Ladeber FP.Joint distraction as treatment for ankle osteoarthritis. 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