{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:52:27Z","timestamp":1787021547853,"version":"build-2736575974"},"reference-count":31,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Haemophilia is an x-linked inherited bleeding disorder which can cause severe arthropathy. We have reviewed the results of 70 primary total knee replacements (TKR) performed in 57 haemophilic patients between 1983 and 2007. The functional results were assessed using the Hospital for Special Surgery (HSS) knee scoring system and Kaplan-Meier survivorship analysis. Six patients died. HSS scores were available for 60 TKRs at a mean follow-up of 9.2 years (2 to 23); 57 (95%) had good or excellent results. Deep infection was recorded in one patient. Kaplan-Meier analysis using infection and aseptic loosening as endpoints showed the survival rate at 20 years to be 94.0%.<\/jats:p>\n                  <jats:p>A reduction in infection, spontaneous haemarthrosis and improvement in the quality of life were noted to justify surgery in our series of patients with a mean age of 43 (25 to 70). We have found that using the latest techniques of continuous infusion of clotting Factor have significantly helped to reduce the complication rates and have achieved results which match those of the non-haemophilic population undergoing TKR.<\/jats:p>","DOI":"10.1302\/0301-620x.92b8.23922","type":"journal-article","created":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T19:17:50Z","timestamp":1280603870000},"page":"1085-1089","source":"Crossref","is-referenced-by-count":87,"title":["Total knee replacement in patients with end-stage haemophilic arthropathy"],"prefix":"10.1302","volume":"92-B","author":[{"given":"N. J.","family":"Goddard","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopedics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Katherine Dormandy Centre of Haemostasis, The Royal Free Hospital, Pond Street, London NW3 2PS, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Arnold WD, Hilgartner MW.\n                      Hemophilic arthropathy: current concepts of pathogenesis and management. J Bone Joint Surg [Am] 1977;59-A:287\u2013305.","DOI":"10.2106\/00004623-197759030-00001"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.63B4.7298694"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615621"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4231"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01535.x"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Figgie MP, Goldberg VM, Figgie HE 3rd, Heiple KG, Sobel M.\n                      Total knee arthroplasty for the treatment of chronic hemophilic arthropathy. Clin Orthop 1989;248:98\u2013107.","DOI":"10.1097\/00003086-198911000-00017"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199903000-00020"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Lachiewicz PF, Inglis AE, Insall JN, et al.\n                      Total knee arthroplasty in hemophilia. J Bone Joint Surg [Am] 1985;67-A:1361\u20136.","DOI":"10.2106\/00004623-198567090-00009"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(05)80065-8"},{"key":"R10","unstructured":"Vastel L, Courpied JP, Sultan Y, Kerboull M.\n                      Knee replacement arthroplasty in hemophilia: results, complications and predictive elements of their occurrence. Rev Chir Orthop Reparatrice Appar Mot 1999;85:458\u201365 (in French)."},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Silva M, Luck JV Jr.\n                      Long-term results of primary total knee replacement in patients with hemophilia. J Bone Joint Surg [Am] 2005;87-A:85\u201391.","DOI":"10.2106\/JBJS.C.01609"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Norian JM, Ries MD, Karp S, Hambleton J.\n                      Total knee arthroplasty in hemophilic arthropathy. 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J Bone Joint Surg [Am] 1981;63-A:695\u2013701.","DOI":"10.2106\/00004623-198163050-00002"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.65B2.6826622"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Magone JB, Dennis DA, Weis LD.\n                      Total knee arthroplasty in chronic hemophilic arthropathy. Orthopedics 1986;9:653\u20137.","DOI":"10.3928\/0147-7447-19860501-09"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.70B3.3131346"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Luck JV Jr, Kasper CK.\n                      Surgical management of advanced hemophilic arthropathy: an overview of 20 years\u2019 experience. 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