{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:37:25Z","timestamp":1783463845952,"version":"3.55.0"},"reference-count":15,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p> We describe a case of bilateral weakness of the lower limbs, sensory disturbance and intermittent urinary incontinence, secondary to untreated Gitelman\u2019s syndrome, in a 42-year-old female who was referred with presumed cauda equina syndrome. On examination, the power of both legs was uniformly reduced, and the perianal and lower-limb sensation was altered. However, MRI of the lumbar spine was normal. Measurements of serum and urinary potassium were low and blood gas analysis revealed metabolic alkalosis. Her symptoms resolved following potassium replacement. <\/jats:p><jats:p> We emphasise the importance of measurement of the plasma and urinary levels of electrolytes in the investigation of patients with paralysis of the lower limbs and suggest that they, together with blood gas analysis, allow the exclusion of unusual causes of muscle weakness resulting from metabolic disorders such as metabolic alkalosis. <\/jats:p>","DOI":"10.1302\/0301-620x.93b2.25700","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:15:08Z","timestamp":1296519308000},"page":"266-268","source":"Crossref","is-referenced-by-count":4,"title":["Gitelman\u2019s syndrome"],"prefix":"10.1302","volume":"93-B","author":[{"given":"C. S.","family":"Quinlan","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Vincent\u2019s University Hospital, Elm Park, Dublin 4, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Vincent\u2019s University Hospital, Elm Park, Dublin 4, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-M.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Vincent\u2019s University Hospital, Elm Park, Dublin 4, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Vincent\u2019s University Hospital, Elm Park, Dublin 4, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, St. Vincent\u2019s University Hospital, Elm Park, Dublin 4, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0321-1"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-22"},{"key":"R3","unstructured":"Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians 1966;79:221\u201335."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/ng.118"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.127993"},{"key":"R6","unstructured":"Medical Research Council. Aids to the examination of the peripheral nervous system, Memorandum no. 45. London: Her Majesty\u2019s Stationery Office, 1981."},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-24"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200112000-00004"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Hisakawa N, Yasuoka N, Itoh H, et al. A case of Gitelman\u2019s syndrome with chondrocalcinosis. Endocrinology Journal 1998;45:261\u20137.","DOI":"10.1507\/endocrj.45.261"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg249"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101095"},{"key":"R12","unstructured":"Yaqoob MM. Water, electrolytes and acid-base balance. In: Kumar P, Clarke M, eds. Clinical medicine. Fifth ed. London: W. B. 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