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The MEDLINE, EMBASE and COCHRANE databases were searched from their inception to May 2010 for all trials involving the use of cross-linked polyethylene in total hip replacement. Eligibility for inclusion in the review included the random allocation of treatments, the use of cross-linked and conventional polyethylene, and radiological wear as an outcome measure. The pooled mean differences were calculated for bedding-in, linear wear rate, three-dimensional linear wear rate, volumetric wear rate and total linear wear. Pooled risk ratios were calculated for radiological osteolysis and revision hip replacement. A search of the literature identified 194 potential studies, of which 12 met the inclusion criteria. All reported a significant reduction in radiological wear for cross-linked polyethylene.<\/jats:p><jats:p>The pooled mean differences for linear rate of wear, three-dimensional linear rate of wear, volumetric wear rate and total linear wear were all significantly reduced for cross-linked polyethylene. The risk ratio for radiological osteolysis was 0.40 (95% confidence interval 0.27 to 0.58; I<jats:sup>2<\/jats:sup>= 0%), favouring cross-linked polyethylene. The follow-up was not long enough to show a difference in the need for revision surgery.<\/jats:p>","DOI":"10.1302\/0301-620x.93b5.25908","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T16:23:37Z","timestamp":1303403017000},"page":"593-600","source":"Crossref","is-referenced-by-count":91,"title":["Cross-linked<i>versus<\/i>conventional polyethylene for total hip replacement"],"prefix":"10.1302","volume":"93-B","author":[{"given":"P. R. 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