{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:52:01Z","timestamp":1758905521242},"reference-count":13,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p> Injectable collagenase is an alternative to surgical treatment for Dupuytren\u2019s disease. Previous studies have reported on the effectiveness of collagenase in finger contractures. This prospective study reports on the short-term safety and efficacy of collagenase treatment in five thumb and first web space Dupuytren\u2019s contractures. The thumb and first web space contractures were treated with injectable collagenase in four consecutive patients (five hands) with experience of previous surgical digital fasciectomy. The thumb contracture was measured by angle and span in two planes of thumb extension and abduction before injection and after manipulation. Collagenase treatment resulted in release of the contracture with a mean increase in thumb to index angle from 23\u00b0 (10\u00b0 to 35\u00b0) to 56\u00b0 (45\u00b0 to 60\u00b0) in extension and from 30\u00b0 (10\u00b0 to 50\u00b0) to 58\u00b0 (50\u00b0 to 65\u00b0) in abduction and a mean increase in span from 1.9 cm (1 to 3.5) to 3.9 cm (3 to 5) in extension and from 2.4 cm (1.5 to 3.5) to 3.9 cm (3 to 4.5) in abduction. All patients reported an increased range of movement and function and described collagenase therapy as preferable to surgery. In the short-term collagenase is an effective, well-tolerated and safe alternative to surgery for Dupuytren\u2019s disease of the thumb. <\/jats:p>","DOI":"10.1302\/0301-620x.94b10.29331","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T01:57:24Z","timestamp":1348711044000},"page":"1390-1392","source":"Crossref","is-referenced-by-count":18,"title":["Collagenase for Dupuytren\u2019s disease of the thumb"],"prefix":"10.1302","volume":"94-B","author":[{"given":"C. L.","family":"Bendon","sequence":"first","affiliation":[{"name":"Oxford University Hospitals NHS Trust, Department\rof Plastic, Reconstructive and Hand Surgery, John\rRadcliffe Hospital, Oxford OX3 9DU, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Giele","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Trust, Department\rof Plastic, Reconstructive and Hand Surgery, John\rRadcliffe Hospital, Oxford OX3 9DU, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/0072-968X(76)90013-9"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHSB.2006.05.005"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1054\/JHSB.2002.0840"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1177\/1753193408087025"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410376286"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(96)80368-6"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.08.007"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.04.002"},{"key":"r10","unstructured":"Peimer CA, Blazar P, Coleman S, et al. Long-term evaluation of Dupuytren\u2019s contracture recurrence following treatment with collagenase clostridium histolyticim (CORDLESS). Procs American Association for Hand Surgery (AAHS) Annual Meeting, 2011."},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.01.003"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(92)90129-P"},{"key":"r13","doi-asserted-by":"crossref","unstructured":"Holzer LA, Holzer G. Collagenase ClostridIum histolyticum in the management of Dupuytren's contracture. Handchir Mikrochir Plast Chir 2011;43:269\u2013274 (in German).","DOI":"10.1055\/s-0031-1286314"}],"container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.94B10.29331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.94B10.29331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.94B10.29331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T18:38:03Z","timestamp":1629139083000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.94B10.29331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1302\/0301-620X.94B10.29331"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.94b10.29331","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}