{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:41:40Z","timestamp":1775036500664,"version":"3.50.1"},"reference-count":19,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p> We examined whether enamel matrix derivative (EMD) could improve healing of the tendon\u2013bone interface following reconstruction of the anterior cruciate ligament (ACL) using a hamstring tendon in a rat model. ACL reconstruction was performed in both knees of 30 Sprague-Dawley rats using the flexor digitorum tendon. The effect of commercially available EMD (EMDOGAIN), a preparation of matrix proteins from developing porcine teeth, was evaluated. In the left knee joint the space around the tendon\u2013bone interface was filled with 40 \u00b5l of EMD mixed with propylene glycol alginate (PGA). In the right knee joint PGA alone was used. The ligament reconstructions were evaluated histologically and biomechanically at four, eight and 12 weeks (n = 5 at each time point). At eight weeks, EMD had induced a significant increase in collagen fibres connecting to bone at the tendon\u2013bone interface (p = 0.047), whereas the control group had few fibres and the tendon\u2013bone interface was composed of cellular and vascular fibrous tissues. At both eight and 12 weeks, the mean load to failure in the treated specimens was higher than in the controls (p = 0.009). EMD improved histological tendon\u2013bone healing at eight weeks and biomechanical healing at both eight and 12 weeks. EMD might therefore have a human application to enhance tendon\u2013bone repair in ACL reconstruction. <\/jats:p>","DOI":"10.1302\/0301-620x.94b2.26904","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T20:16:57Z","timestamp":1328732217000},"page":"205-209","source":"Crossref","is-referenced-by-count":21,"title":["Acceleration of tendon\u2013bone healing in anterior cruciate ligament reconstruction using an enamel matrix derivative in a rat model"],"prefix":"10.1302","volume":"94-B","author":[{"given":"Y.","family":"Kadonishi","sequence":"first","affiliation":[{"name":"Hiroshima University, Kasumi\r1-2-3, Minami-ku, Hiroshima-City\r734-8551, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deie","sequence":"additional","affiliation":[{"name":"Hiroshima University, Kasumi\r1-2-3, Minami-ku, Hiroshima-City\r734-8551, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Takata","sequence":"additional","affiliation":[{"name":"Hiroshima University, Kasumi\r1-2-3, Minami-ku, Hiroshima-City\r734-8551, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ochi","sequence":"additional","affiliation":[{"name":"Hiroshima University, Kasumi\r1-2-3, Minami-ku, Hiroshima-City\r734-8551, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-008-0610-z"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0059"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1007\/s001670050006"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200207000-00005"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199312000-00009"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1177\/03635465990270041201"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508316282"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(04)00653-X"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"r10","unstructured":"Rasband WS. 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