{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:33:10Z","timestamp":1790836390693,"version":"4.1.0"},"reference-count":13,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery. British volume"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    Autologous chondrocyte implantation (ACI) and mosaicplasty are methods of treating symptomatic articular cartilage defects in the knee. This study represents the first long-term randomised comparison of the two techniques in 100 patients at a minimum follow-up of ten years. The mean age of the patients at the time of surgery was 31.3 years (16 to 49); the mean duration of symptoms pre-operatively was 7.2 years (9 months to 20 years). The lesions were large with the mean size for the ACI group being 440.9 mm\n                    <jats:sup>2<\/jats:sup>\n                    (100 to 1050) and the mosaicplasty group being 399.6 mm\n                    <jats:sup>2<\/jats:sup>\n                    (100 to 2000). Patients had a mean of 1.5 previous operations (0 to 4) to the articular cartilage defect. Patients were assessed using the modified Cincinnati knee score and the Stanmore-Bentley Functional Rating system. The number of patients whose repair had failed at ten years was ten of 58 (17%) in the ACI group and 23 of 42 (55%) in the mosaicplasty group (p &lt; 0.001).\n                  <\/jats:p>\n                  <jats:p>The functional outcome of those patients with a surviving graft was significantly better in patients who underwent ACI compared with mosaicplasty (p = 0.02).<\/jats:p>","DOI":"10.1302\/0301-620x.94b4.27495","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T07:48:31Z","timestamp":1332229711000},"page":"504-509","source":"Crossref","is-referenced-by-count":234,"title":["Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation\n                    <i>versus<\/i>\n                    mosaicplasty for symptomatic articular cartilage lesions of the knee"],"prefix":"10.1302","volume":"94-B","author":[{"given":"G.","family":"Bentley","sequence":"first","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Biant","sequence":"additional","affiliation":[{"name":"The Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Macmull","sequence":"additional","affiliation":[{"name":"Barnet and Chase Farm Hospitals, Wellhouse Lane, Barnet EN5 3DJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. J.","family":"Carrington","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-19980701-04"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B9.22490"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B2.13543"},{"key":"r5","unstructured":"Bentley G.\n                      Degradation, repair and regeneration of articular cartilage\n                      . ChM thesis. Sheffield: University of Sheffield, 1972."},{"key":"r6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00003086-198909000-00034","volume":"246","author":"Noyes FR","year":"1989","journal-title":"Clin Orthop"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B6.0800965"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2009.12.004"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000131638.81519.de"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199704000-00022"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200005000-00020"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508330137"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0998-0"}],"container-title":["The Journal of Bone and Joint Surgery. British volume"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.94B4.27495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.94B4.27495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.94B4.27495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:59:48Z","timestamp":1641365988000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.94B4.27495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1302\/0301-620X.94B4.27495"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.94b4.27495","relation":{},"ISSN":["0301-620X","2044-5377"],"issn-type":[{"value":"0301-620X","type":"print"},{"value":"2044-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}