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We performed a meta-analysis of 30 clinical studies on the diagnosis of suspected scaphoid fractures, in which agreement data between any of follow-up radiographs, bone scintigraphy, magnetic resonance (MR) imaging, or CT could be obtained, and combined this with latent class analysis to infer the accuracy of these tests on the diagnosis of suspected scaphoid fractures in the absence of an established standard. The estimated sensitivity and specificity were respectively 91.1% and 99.8% for follow-up radiographs, 97.8% and 93.5% for bone scintigraphy, 97.7% and 99.8% for MRI, and 85.2% and 99.5% for CT. The results were generally robust in multiple sensitivity analyses. There was large between-study heterogeneity for the sensitivity of follow-up radiographs and CT, and imprecision about their sensitivity estimates.<\/jats:p><jats:p>If we acknowledge the lack of a reference standard for diagnosing suspected scaphoid fractures, MRI is the most accurate test; follow-up radiographs and CT may be less sensitive, and bone scintigraphy less specific.<\/jats:p>","DOI":"10.1302\/0301-620x.94b8.28998","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T08:37:00Z","timestamp":1343464620000},"page":"1077-1085","source":"Crossref","is-referenced-by-count":57,"title":["Diagnostic accuracy of imaging modalities for suspected scaphoid fractures"],"prefix":"10.1302","volume":"94-B","author":[{"given":"Z-G.","family":"Yin","sequence":"first","affiliation":[{"name":"Tianjin Orthopaedic Hospital, Department of Hand Surgery, Tianjin 300200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Orthopaedic Hospital, Department of Hand Surgery, Tianjin 300200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-L.","family":"Kan","sequence":"additional","affiliation":[{"name":"Tianjin Orthopaedic Hospital, Department of Hand Surgery, Tianjin 300200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-G.","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Orthopaedic Hospital, Department of Hand Surgery, Tianjin 300200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B6.26506"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984566"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3181f9de26"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2005.07.001"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01523"},{"key":"r6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1742-6723.2007.00959.x","volume":"19","author":"Cruickshank J","year":"2007","journal-title":"Emerg Med Australas"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1081-6"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1383(92)90035-Q"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.3310\/hta11500"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00086-4"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290071040"},{"key":"r12","unstructured":"No authors listed.The Pennsylvania State University: PROC LCA & PROC LTA Software FAQ. http:\/\/methodology.psu.edu\/ra\/lcalta\/faq (date last accessed 20 April 2012)."},{"key":"r13","unstructured":"Macaskill P, Gatsonis C, Deeks JJ, Harbord RM, Takwoingi YChapter 10: Analysing and Presenting Results. 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